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Gene Review

Usf1  -  upstream transcription factor 1

Mus musculus

Synonyms: Major late transcription factor 1, Upstream stimulatory factor 1, Usf, bHLHb11, upstream stimulatory factor
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Disease relevance of Usf1


High impact information on Usf1

  • The B2 pol II promoters can be bound and stimulated by the transcription factor USF (for upstream stimulatory factor), as shown by transient transfection experiments [3].
  • The major late transcription factor binds to and activates the mouse metallothionein I promoter [4].
  • The results suggest that activation of Usf-1 by p38 at a wide variety of viral and cellular promoters will provide a link between stimuli as diverse as UV irradiation, glucose, viral infection and pro-inflammatory cytokines, and the changes in gene expression associated with the stress response [5].
  • We reported that upstream stimulatory factor binding to the -65 E-box is required for induction of the FAS transcription by insulin in 3T3-L1 adipocytes [6].
  • By using a formaldehyde crosslinking procedure and Gal4 fusion proteins, we have analyzed the timing and functional consequences of binding of Myc and upstream stimulatory factor (USF)1 to endogenous cellular genes [7].

Biological context of Usf1


Anatomical context of Usf1


Associations of Usf1 with chemical compounds


Physical interactions of Usf1


Regulatory relationships of Usf1

  • Furthermore, we have demonstrated that Ik-2 and upstream stimulatory factor synergize in trans-activating the dor promoter via the putative Ik-binding site and the E box, respectively [14].

Other interactions of Usf1


Analytical, diagnostic and therapeutic context of Usf1


  1. The mouse thymidylate synthase promoter: essential elements are in close proximity to the transcriptional initiation sites. Deng, T., Li, Y., Jolliff, K., Johnson, L.F. Mol. Cell. Biol. (1989) [Pubmed]
  2. Promoter sequences of varicella-zoster virus glycoprotein I targeted by cellular transactivating factors Sp1 and USF determine virulence in skin and T cells in SCIDhu mice in vivo. Ito, H., Sommer, M.H., Zerboni, L., He, H., Boucaud, D., Hay, J., Ruyechan, W., Arvin, A.M. J. Virol. (2003) [Pubmed]
  3. Transposable B2 SINE elements can provide mobile RNA polymerase II promoters. Ferrigno, O., Virolle, T., Djabari, Z., Ortonne, J.P., White, R.J., Aberdam, D. Nat. Genet. (2001) [Pubmed]
  4. The major late transcription factor binds to and activates the mouse metallothionein I promoter. Carthew, R.W., Chodosh, L.A., Sharp, P.A. Genes Dev. (1987) [Pubmed]
  5. The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression. Galibert, M.D., Carreira, S., Goding, C.R. EMBO J. (2001) [Pubmed]
  6. Nutritional regulation of the fatty acid synthase promoter in vivo: sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element. Latasa, M.J., Moon, Y.S., Kim, K.H., Sul, H.S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  7. c-Myc target gene specificity is determined by a post-DNAbinding mechanism. Boyd, K.E., Wells, J., Gutman, J., Bartley, S.M., Farnham, P.J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  8. Upstream stimulatory factor 2 stimulates transcription through an initiator element in the mouse cytochrome c oxidase subunit Vb promoter. Breen, G.A., Jordan, E.M. Biochim. Biophys. Acta (2000) [Pubmed]
  9. Oxidative stress activates metal-responsive transcription factor-1 binding activity. Occupancy in vivo of metal response elements in the metallothionein-I gene promoter. Dalton, T.P., Li, Q., Bittel, D., Liang, L., Andrews, G.K. J. Biol. Chem. (1996) [Pubmed]
  10. Transcriptional regulation of mouse delta-opioid receptor gene. Liu, H.C., Shen, J.T., Augustin, L.B., Ko, J.L., Loh, H.H. J. Biol. Chem. (1999) [Pubmed]
  11. Two 5'-regions are required for nutritional and insulin regulation of the fatty-acid synthase promoter in transgenic mice. Moon, Y.S., Latasa, M.J., Kim, K.H., Wang, D., Sul, H.S. J. Biol. Chem. (2000) [Pubmed]
  12. Participation of upstream stimulator factor (USF) in cadmium-induction of the mouse metallothionein-I gene. Li, Q., Hu, N., Daggett, M.A., Chu, W.A., Bittel, D., Johnson, J.A., Andrews, G.K. Nucleic Acids Res. (1998) [Pubmed]
  13. The transcription factors MTF-1 and USF1 cooperate to regulate mouse metallothionein-I expression in response to the essential metal zinc in visceral endoderm cells during early development. Andrews, G.K., Lee, D.K., Ravindra, R., Lichtlen, P., Sirito, M., Sawadogo, M., Schaffner, W. EMBO J. (2001) [Pubmed]
  14. Transcriptional regulation of mouse delta-opioid receptor gene. Ikaros-2 and upstream stimulatory factor synergize in trans-activating mouse delta-opioid receptor gene in T cells. Sun, P., Loh, H.H. J. Biol. Chem. (2003) [Pubmed]
  15. Osteopontin transcription in aortic vascular smooth muscle cells is controlled by glucose-regulated upstream stimulatory factor and activator protein-1 activities. Bidder, M., Shao, J.S., Charlton-Kachigian, N., Loewy, A.P., Semenkovich, C.F., Towler, D.A. J. Biol. Chem. (2002) [Pubmed]
  16. B cell-specific activator protein prevents two activator factors from binding to the immunoglobulin J chain promoter until the antigen-driven stages of B cell development. Wallin, J.J., Rinkenberger, J.L., Rao, S., Gackstetter, E.R., Koshland, M.E., Zwollo, P. J. Biol. Chem. (1999) [Pubmed]
  17. The activation and composition of FiRE (an FGF-inducible response element) differ in a cell type- and growth factor-specific manner. Jaakkola, P., Määttä, A., Jalkanen, M. Oncogene (1998) [Pubmed]
  18. Glucocorticoid inhibition of transcription from adenovirus major late promoter. Mahajan, P.B., Thompson, E.A. Mol. Endocrinol. (1990) [Pubmed]
  19. The basic region/helix-loop-helix/leucine repeat transcription factor USF interferes with Ras transformation. Aperlo, C., Boulukos, K.E., Pognonec, P. Eur. J. Biochem. (1996) [Pubmed]
  20. Recognition of the E-C4 element from the C4 complement gene promoter by the upstream stimulatory factor-1 transcription factor. Galibert, M.D., Boucontet, L., Goding, C.R., Meo, T. J. Immunol. (1997) [Pubmed]
  21. An indirect role for upstream stimulatory factor in glucose-mediated induction of pyruvate kinase and S14 gene expression. Kaytor, E.N., Qian, J., Towle, H.C., Olson, L.K. Mol. Cell. Biochem. (2000) [Pubmed]
  22. Synergistic role of specificity proteins and upstream stimulatory factor 1 in transactivation of the mouse carboxylesterase 2/microsomal acylcarnitine hydrolase gene promoter. Furihata, T., Hosokawa, M., Satoh, T., Chiba, K. Biochem. J. (2004) [Pubmed]
  23. Upstream stimulatory factor binding to the E-box at -65 is required for insulin regulation of the fatty acid synthase promoter. Wang, D., Sul, H.S. J. Biol. Chem. (1997) [Pubmed]
  24. An E-box region within the prostaglandin endoperoxide synthase-2 (PGS-2) promoter is required for transcription in rat ovarian granulosa cells. Morris, J.K., Richards, J.S. J. Biol. Chem. (1996) [Pubmed]
  25. USF-1 and USF-2 trans-repress IL-1beta-induced iNOS transcription in mesangial cells. Gupta, A.K., Kone, B.C. Am. J. Physiol., Cell Physiol. (2002) [Pubmed]
  26. Murine chromosomal location of five bHLH-Zip transcription factor genes. Steingrímsson, E., Sawadogo, M., Gilbert, D.J., Zervos, A.S., Brent, R., Blanar, M.A., Fisher, D.E., Copeland, N.G., Jenkins, N.A. Genomics (1995) [Pubmed]
  27. Insulin regulation of fatty acid synthase gene transcription: roles of USF and SREBP-1c. Griffin, M.J., Sul, H.S. IUBMB Life (2004) [Pubmed]
  28. Regulation of the murine Ddelta2 promoter by upstream stimulatory factor 1, Runx1, and c-Myb. Carabana, J., Ortigoza, E., Krangel, M.S. J. Immunol. (2005) [Pubmed]
  29. The concerted regulatory functions of the transcription factors nuclear factor-1 and upstream stimulatory factor on a composite element in the promoter of the hepatocyte growth factor gene. Jiang, J.G., Gao, B., Zarnegar, R. Oncogene (2000) [Pubmed]
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