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Gene Review

S100A16  -  S100 calcium binding protein A16

Homo sapiens

Synonyms: AAG13, Aging-associated gene 13 protein, DT1P1A7, MGC17528, Protein S100-A16, ...
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Disease relevance of S100A16


High impact information on S100A16

  • S100A16, a Novel Calcium-binding Protein of the EF-hand Superfamily [1].
  • Trp fluorescence variations indicate conformational changes in the orthologous proteins upon Ca(2+) binding, whereas formation of a hydrophobic patch, implicated in target protein recognition, only occurs in the human S100A16 protein [1].
  • Up-regulation of S100A16 was found in many tumors implying a central cellular function related to malignant transformation [2].

Biological context of S100A16

  • S100A16 protein is a new and unique member of the EF-hand Ca(2+)-binding proteins [1].

Associations of S100A16 with chemical compounds

  • Flow dialysis revealed that both homodimeric S100A16 proteins bind two Ca(2+) ions with the C-terminal EF-hand of each subunit, the human protein exhibiting a 2-fold higher affinity [1].


  1. S100A16, a Novel Calcium-binding Protein of the EF-hand Superfamily. Sturchler, E., Cox, J.A., Durussel, I., Weibel, M., Heizmann, C.W. J. Biol. Chem. (2006) [Pubmed]
  2. S100A16, a ubiquitously expressed EF-hand protein which is up-regulated in tumors. Marenholz, I., Heizmann, C.W. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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