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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

fr  -  frizzy

Mus musculus

This record was replaced with 76560.
 
 
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High impact information on fr

  • Analysis of this panel has located the CR hairless rat's hypotrichosis-generating mutation on chromosome 1, near Myl2, where only the fuzzy mutation in rat (fz) and the frizzy mutation in mouse (fr) have been previously localized [1].
  • The Charles River "hairless" rat mutation maps to chromosome 1: allelic with fuzzy and a likely orthologue of mouse frizzy [1].
 

Biological context of fr

  • The results prove that a major gene does exist, that it is very closely linked with frizzy, fr, in chromosome 7, which in turn is linked with ce, that it is fully dominant in females at 4 months of age, and that its partial dominance in males is under the control of modifiers [2].

References

  1. The Charles River "hairless" rat mutation maps to chromosome 1: allelic with fuzzy and a likely orthologue of mouse frizzy. Ahearn, K., Akkouris, G., Berry, P.R., Chrissluis, R.R., Crooks, I.M., Dull, A.K., Grable, S., Jeruzal, J., Lanza, J., Lavoie, C., Maloney, R.A., Pitruzzello, M., Sharma, R., Stoklasek, T.A., Tweeddale, J., King, T.R. J. Hered. (2002) [Pubmed]
  2. A major gene controlling warfarin-resistance in the house mouse. Wallace, M.E., MacSwiney, F.J. The Journal of hygiene. (1976) [Pubmed]
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