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Gene Review:

orf15 - hypothetical protein

Escherichia coli

Arulanantham, H. et al.

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High impact information on orf15

The specificity of ORF17 as an N-glycyl-clavaminic acid synthetase, together with the reported accumulation of N-glycyl-clavaminic acid in orf15 and orf16 disruption mutants, suggested that N-glycyl-clavaminic acid is an intermediate in clavulanic acid biosynthesis [1].

Biological context of orf15

Disruption of orf15 or orf16, of the clavulanic acid biosynthesis gene cluster, blocks clavulanic acid production and leads to the accumulation of N-acetyl-glycyl-clavaminic acid and N-glycyl-clavaminic acid, suggesting that these compounds are intermediates in the pathway [1].

References

ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid. Arulanantham, H., Kershaw, N.J., Hewitson, K.S., Hughes, C.E., Thirkettle, J.E., Schofield, C.J. J. Biol. Chem. (2006) [Pubmed]

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