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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

hsdS  -  hypothetical protein

Lactococcus lactis

 
 
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Disease relevance of hsdS

  • When introduced into L. lactis IL1403, the HsdS of pSRQ800 and pSRQ900 conferred a weak resistance against phage P008 (936 species) [1].
 

High impact information on hsdS

  • The ORF1's are predicted to encode type I restriction-modification (R-M) system HsdS subunits with different specificities on either plasmid, suggesting that these plasmids may be involved in host defense by expanding their host R-M system repertoire [2].
 

Biological context of hsdS

  • The theta replication regions of the three plasmids were associated with two additional coding regions, one of which encodes for HsdS, the specificity subunit of the type I restriction/modification system [1].

References

  1. DNA sequence analysis of three Lactococcus lactis plasmids encoding phage resistance mechanisms. Boucher, I., Emond, E., Parrot, M., Moineau, S. J. Dairy Sci. (2001) [Pubmed]
  2. DNA sequence and functional analysis of Lactobacillus delbrueckii subsp. lactis plasmids pN42 and pJBL2. Bourniquel, A.A., Casey, M.G., Mollet, B., Pridmore, R.D. Plasmid (2002) [Pubmed]
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