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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

merA  -  mercuric reductase

Sulfolobus solfataricus P2

 
 
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High impact information on merA

  • Northern blot and primer extension analyses identified two additional Hg(II)-inducible S. solfataricus genes, merH and merI (SSO2690), located on either side of merA [1].
  • Northern analysis of the merR mutant revealed merA transcription was constitutive and that transcript abundance was at maximum levels [2].
  • Primer extension analysis of merA mRNA predicted a noncanonical TATA box with nonstandard transcription start site spacing [2].
  • Northern analysis established that merA transcription responded to mercury challenge, since mRNA levels were transiently induced and, when normalized to 7S RNA, approximated values for other highly expressed transcripts [2].

References

  1. Regulation of Mercury Resistance in the Crenarchaeote Sulfolobus solfataricus. Schelert, J., Drozda, M., Dixit, V., Dillman, A., Blum, P. J. Bacteriol. (2006) [Pubmed]
  2. Occurrence and characterization of mercury resistance in the hyperthermophilic archaeon Sulfolobus solfataricus by use of gene disruption. Schelert, J., Dixit, V., Hoang, V., Simbahan, J., Drozda, M., Blum, P. J. Bacteriol. (2004) [Pubmed]
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