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Gene Review

C2CD4A  -  C2 calcium-dependent domain containing 4A

Homo sapiens

Synonyms: C2 calcium-dependent domain-containing protein 4A, FAM148A, NLF1, Nuclear-localized factor 1, Protein FAM148A
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High impact information on NLF1

  • We propose that NLF1 and NLF2 belong to a novel gene family encoding nuclear factors with a role in regulating genes which control cellular architecture [1].
  • Furthermore, two sequences with homology to NF-kappaB binding sites in the promoter of NLF1 were found to be essential for rapid elevation in expression in response to interleukin 1beta [1].
  • NLF1 and NLF2 transcripts were found predominantly in endothelial cells, and the encoded proteins were localised to the nuclear compartment suggesting a role in the regulation of transcription [1].
  • In contrast, apoptosis was only observed in the motor neurons derived from control (C57bl/6) or hNLF (+/+) mice at 24 hours [2].


  1. A novel gene family induced by acute inflammation in endothelial cells. Warton, K., Foster, N.C., Gold, W.A., Stanley, K.K. Gene (2004) [Pubmed]
  2. In vitro reactive nitrating species toxicity in dissociated spinal motor neurons from NFL (-/-) and hNFL (+/+) transgenic mice. Strong, M., Sopper, M., He, B.P. Amyotroph. Lateral Scler. Other Motor Neuron Disord. (2003) [Pubmed]
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