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Gene Review:

B1R - B1R

Variola virus

Santos, C.R. et al., Webb, T.J. et al.

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Disease relevance of B1R

Vaccinia virus has an early Ser-Thr kinase, B1R, which, although required for successful viral infection, is poorly characterized regarding its effects on cellular proteins, and thus, its potential contribution to pathogenesis is not known [1].

High impact information on B1R

It is shown here that the VV-encoded molecules, B1R and H5R, play a role in the ability of VV to inhibit CD1d-mediated antigen presentation to NKT cells [2].

References

Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling. Santos, C.R., Blanco, S., Sevilla, A., Lazo, P.A. J. Virol. (2006) [Pubmed]
Inhibition of CD1d1-mediated antigen presentation by the vaccinia virus B1R and H5R molecules. Webb, T.J., Litavecz, R.A., Khan, M.A., Du, W., Gervay-Hague, J., Renukaradhya, G.J., Brutkiewicz, R.R. Eur. J. Immunol. (2006) [Pubmed]

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