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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Antigen Presentation

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Disease relevance of Antigen Presentation


High impact information on Antigen Presentation


Chemical compound and disease context of Antigen Presentation


Biological context of Antigen Presentation


Anatomical context of Antigen Presentation

  • These class II MHC-rich, multivesicular endosomes receive incoming antigen and can support not only antigen processing and class II MHC peptide loading but also the export of peptide/class II MHC complexes to the cell surface [21].
  • MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation [22].
  • The transporter associated with the antigen processing 1 (TAP1) gene encodes a subunit for a transporter, presumed to be involved in the delivery of peptides across the endoplasmic reticulum membrane to class I molecules [23].
  • This discrepancy is generally explained by the idea that IFN-gamma either directly activates macrophages, or, by increasing antigen presentation, indirectly activates T cells within the lesions of atherosclerosis and graft arteriosclerosis [24].
  • Evidence for such a function has come from the rescue of class I surface expression by a cloned copy of the human homologue of Ham-1, PSF-1, in a human cell line that is defective in antigen processing [25].

Associations of Antigen Presentation with chemical compounds


Gene context of Antigen Presentation


Analytical, diagnostic and therapeutic context of Antigen Presentation


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  2. PPARgamma promotes mannose receptor gene expression in murine macrophages and contributes to the induction of this receptor by IL-13. Coste, A., Dubourdeau, M., Linas, M.D., Cassaing, S., Lepert, J.C., Balard, P., Chalmeton, S., Bernad, J., Orfila, C., Séguéla, J.P., Pipy, B. Immunity (2003) [Pubmed]
  3. Structural requirements for class I MHC molecule-mediated antigen presentation and cytotoxic T cell recognition of an immunodominant determinant of the human immunodeficiency virus envelope protein. Takahashi, H., Houghten, R., Putney, S.D., Margulies, D.H., Moss, B., Germain, R.N., Berzofsky, J.A. J. Exp. Med. (1989) [Pubmed]
  4. Retention of adenovirus E19 glycoprotein in the endoplasmic reticulum is essential to its ability to block antigen presentation. Cox, J.H., Bennink, J.R., Yewdell, J.W. J. Exp. Med. (1991) [Pubmed]
  5. Reactive lymphocytes in lacrimal gland and vasculitic renal lesions of autoimmune MRL/lpr mice express L3T4. Jabs, D.A., Prendergast, R.A. J. Exp. Med. (1987) [Pubmed]
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  7. Cellular responses to interferon-gamma. Boehm, U., Klamp, T., Groot, M., Howard, J.C. Annu. Rev. Immunol. (1997) [Pubmed]
  8. T cell-dependent B cell activation. Parker, D.C. Annu. Rev. Immunol. (1993) [Pubmed]
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  10. In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes. Kissler, S., Stern, P., Takahashi, K., Hunter, K., Peterson, L.B., Wicker, L.S. Nat. Genet. (2006) [Pubmed]
  11. Asparagine deamidation perturbs antigen presentation on class II major histocompatibility complex molecules. Moss, C.X., Matthews, S.P., Lamont, D.J., Watts, C. J. Biol. Chem. (2005) [Pubmed]
  12. Pentamidine isethionate reduces Ia expression and antigen presentation by Langerhans cells and inhibits the contact hypersensitivity reaction. Blaylock, B.L., Kouchi, Y., Comment, C.E., Corsini, E., Rosenthal, G.J., Luster, M.I. J. Immunol. (1991) [Pubmed]
  13. Transfer of antigen-presenting capacity to Ia-negative cells upon fusion with Ia-bearing liposomes. Coeshott, C., Grey, H.M. J. Immunol. (1985) [Pubmed]
  14. Inhibition of antigen presentation by the glycine/alanine repeat domain is not conserved in simian homologues of Epstein-Barr virus nuclear antigen 1. Blake, N.W., Moghaddam, A., Rao, P., Kaur, A., Glickman, R., Cho, Y.G., Marchini, A., Haigh, T., Johnson, R.P., Rickinson, A.B., Wang, F. J. Virol. (1999) [Pubmed]
  15. Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation. Naisbitt, D.J., Farrell, J., Gordon, S.F., Maggs, J.L., Burkhart, C., Pichler, W.J., Pirmohamed, M., Park, B.K. Mol. Pharmacol. (2002) [Pubmed]
  16. Polysaccharide processing and presentation by the MHCII pathway. Cobb, B.A., Wang, Q., Tzianabos, A.O., Kasper, D.L. Cell (2004) [Pubmed]
  17. Mutations of immunoglobulin transmembrane and cytoplasmic domains: effects on intracellular signaling and antigen presentation. Shaw, A.C., Mitchell, R.N., Weaver, Y.K., Campos-Torres, J., Abbas, A.K., Leder, P. Cell (1990) [Pubmed]
  18. Presentation of CMV immediate-early antigen to cytolytic T lymphocytes is selectively prevented by viral genes expressed in the early phase. Del Val, M., Münch, K., Reddehase, M.J., Koszinowski, U.H. Cell (1989) [Pubmed]
  19. Class II MHC molecules can use the endogenous pathway of antigen presentation. Nuchtern, J.G., Biddison, W.E., Klausner, R.D. Nature (1990) [Pubmed]
  20. Mechanisms of viral interference with MHC class I antigen processing and presentation. Yewdell, J.W., Bennink, J.R. Annu. Rev. Cell Dev. Biol. (1999) [Pubmed]
  21. Capture and processing of exogenous antigens for presentation on MHC molecules. Watts, C. Annu. Rev. Immunol. (1997) [Pubmed]
  22. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Germain, R.N. Cell (1994) [Pubmed]
  23. TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Van Kaer, L., Ashton-Rickardt, P.G., Ploegh, H.L., Tonegawa, S. Cell (1992) [Pubmed]
  24. Interferon-gamma elicits arteriosclerosis in the absence of leukocytes. Tellides, G., Tereb, D.A., Kirkiles-Smith, N.C., Kim, R.W., Wilson, J.H., Schechner, J.S., Lorber, M.I., Pober, J.S. Nature (2000) [Pubmed]
  25. Ham-2 corrects the class I antigen-processing defect in RMA-S cells. Attaya, M., Jameson, S., Martinez, C.K., Hermel, E., Aldrich, C., Forman, J., Lindahl, K.F., Bevan, M.J., Monaco, J.J. Nature (1992) [Pubmed]
  26. An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation. Manoury, B., Hewitt, E.W., Morrice, N., Dando, P.M., Barrett, A.J., Watts, C. Nature (1998) [Pubmed]
  27. Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation. Nuchtern, J.G., Bonifacino, J.S., Biddison, W.E., Klausner, R.D. Nature (1989) [Pubmed]
  28. Tyrosine-containing motif that transduces cell activation signals also determines internalization and antigen presentation via type III receptors for IgG. Amigorena, S., Salamero, J., Davoust, J., Fridman, W.H., Bonnerot, C. Nature (1992) [Pubmed]
  29. Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression. Nabavi, N., Freeman, G.J., Gault, A., Godfrey, D., Nadler, L.M., Glimcher, L.H. Nature (1992) [Pubmed]
  30. The spectrum of IgE-mediated responses to latex. Sussman, G.L., Tarlo, S., Dolovich, J. JAMA (1991) [Pubmed]
  31. Expression of a membrane protease enhances presentation of endogenous antigens to MHC class I-restricted T lymphocytes. Eisenlohr, L.C., Bacik, I., Bennink, J.R., Bernstein, K., Yewdell, J.W. Cell (1992) [Pubmed]
  32. Second proteasome-related gene in the human MHC class II region. Kelly, A., Powis, S.H., Glynne, R., Radley, E., Beck, S., Trowsdale, J. Nature (1991) [Pubmed]
  33. HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells. Fling, S.P., Arp, B., Pious, D. Nature (1994) [Pubmed]
  34. Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40. Tomasec, P., Braud, V.M., Rickards, C., Powell, M.B., McSharry, B.P., Gadola, S., Cerundolo, V., Borysiewicz, L.K., McMichael, A.J., Wilkinson, G.W. Science (2000) [Pubmed]
  35. Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice. Nakagawa, T.Y., Brissette, W.H., Lira, P.D., Griffiths, R.J., Petrushova, N., Stock, J., McNeish, J.D., Eastman, S.E., Howard, E.D., Clarke, S.R., Rosloniec, E.F., Elliott, E.A., Rudensky, A.Y. Immunity (1999) [Pubmed]
  36. Antagonistic effects of gamma interferon and steroids on tissue antigenicity. Leszczynski, D., Ferry, B., Schellekens, H., van der Meide, P.H., Häyry, P. J. Exp. Med. (1986) [Pubmed]
  37. Molecular characterization of defective antigen processing in human prostate cancer. Sanda, M.G., Restifo, N.P., Walsh, J.C., Kawakami, Y., Nelson, W.G., Pardoll, D.M., Simons, J.W. J. Natl. Cancer Inst. (1995) [Pubmed]
  38. Processing and presentation of tumor antigens and vaccination strategies. van der Bruggen, P., Van den Eynde, B.J. Curr. Opin. Immunol. (2006) [Pubmed]
  39. Viral effects on antigen processing. Miller, D.M., Sedmak, D.D. Curr. Opin. Immunol. (1999) [Pubmed]
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