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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Vaccinia


Psychiatry related information on Vaccinia


High impact information on Vaccinia

  • Vaccinia DNA topoisomerase breaks and rejoins DNA strands through a DNA-(3'-phosphotyrosyl)-enzyme intermediate [7].
  • Surprisingly, this domain does not resemble the vaccinia virus capping enzyme but does have significant sequence similarity to the protein tyrosine phosphatase (PTP) enzyme family [8].
  • A soluble receptor for interleukin-1 beta encoded by vaccinia virus: a novel mechanism of virus modulation of the host response to infection [9].
  • Vaccinia virus gene B15R is shown to encode an abundant, secretory glycoprotein that functions as a soluble interleukin-1 (IL-1) receptor [9].
  • Supernatants from vaccinia virus (VV)-infected CV-1 cells were examined and found to contain a 33 kd protein capable of binding murine interleukin-1 beta (mIL-1 beta) [10].

Chemical compound and disease context of Vaccinia


Biological context of Vaccinia


Anatomical context of Vaccinia

  • We isolated mutants whose vaccinia hemagglutinin (HA) accumulates on nuclear envelopes and the rough endoplasmic reticulum [19].
  • Inoculation with the IL-2/vaccinia recombinant virus led, in addition, to drastic reduction of the double-negative T-cell population, improved thymic differentiation and restoration of normal values of mature cells in peripheral lymphoid organs [20].
  • We have constructed recombinant vaccinia viruses that express the ligand for CD40 and have shown that the growth of these viruses is dramatically controlled in vivo, even in mice that lack T or B cells [21].
  • Neural Wiskott-Aldrich syndrome protein (N-WASP) functions in several intracellular events including filopodium formation, vesicle transport and movement of Shigella frexneri and vaccinia virus, by stimulating rapid actin polymerization through the Arp2/3 complex [22].
  • PAC-1 is similar to a phosphatase induced by mitogens or heat shock in fibroblasts, a yeast gene, and a vaccinia virus-encoded serine-tyrosine phosphatase (VH1) [23].

Gene context of Vaccinia

  • We now show that occupancy of the EGF receptor inhibits vaccinia virus infection [24].
  • Epidermal growth factor receptor occupancy inhibits vaccinia virus infection [24].
  • This region has recently been shown to contain a binding region of TGF-alpha for the EGF receptor, and this raises the question of whether vaccinia virus utilizes the EGF receptor in order to bind to and infect cells [24].
  • Tyk2-/- mice are unable to clear vaccinia virus and show a reduced T cell response after LCMV challenge [25].
  • We report here that VHR, a Vaccinia virus VH1-related dual-specific protein phosphatase that inactivates the mitogen-activated kinases Erk2 and Jnk, is phosphorylated at Y138 by ZAP-70 [26].

Analytical, diagnostic and therapeutic context of Vaccinia


  1. A group specific anamnestic immune reaction against HIV-1 induced by a candidate vaccine against AIDS. Zagury, D., Bernard, J., Cheynier, R., Desportes, I., Leonard, R., Fouchard, M., Reveil, B., Ittele, D., Lurhuma, Z., Mbayo, K. Nature (1988) [Pubmed]
  2. Successful vaccination with a polyvalent live vector despite existing immunity to an expressed antigen. Flexner, C., Murphy, B.R., Rooney, J.F., Wohlenberg, C., Yuferov, V., Notkins, A.L., Moss, B. Nature (1988) [Pubmed]
  3. Expression of AIDS virus envelope gene in recombinant vaccinia viruses. Hu, S.L., Kosowski, S.G., Dalrymple, J.M. Nature (1986) [Pubmed]
  4. Inhibition of 40S--Met--tRNAfMet ribosomal initiation complex formation by vaccinia virus. Person, A., Ben-Hamida, F., Beaud, G. Nature (1980) [Pubmed]
  5. Large-scale eradication of rabies using recombinant vaccinia-rabies vaccine. Brochier, B., Kieny, M.P., Costy, F., Coppens, P., Bauduin, B., Lecocq, J.P., Languet, B., Chappuis, G., Desmettre, P., Afiademanyo, K. Nature (1991) [Pubmed]
  6. Thy 1+ asialo GM1+ dendritic epidermal cells in skin defense mechanisms of vaccinia virus-infected mice. Ikeda, S., Tominaga, T., Nishimura, C. Arch. Virol. (1991) [Pubmed]
  7. Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases. Cheng, C., Kussie, P., Pavletich, N., Shuman, S. Cell (1998) [Pubmed]
  8. An RNA 5'-triphosphatase related to the protein tyrosine phosphatases. Takagi, T., Moore, C.R., Diehn, F., Buratowski, S. Cell (1997) [Pubmed]
  9. A soluble receptor for interleukin-1 beta encoded by vaccinia virus: a novel mechanism of virus modulation of the host response to infection. Alcamí, A., Smith, G.L. Cell (1992) [Pubmed]
  10. Vaccinia and cowpox viruses encode a novel secreted interleukin-1-binding protein. Spriggs, M.K., Hruby, D.E., Maliszewski, C.R., Pickup, D.J., Sims, J.E., Buller, R.M., VanSlyke, J. Cell (1992) [Pubmed]
  11. Characterization of the 5' termini of hn RNA in mouse L cells: implications for processing and cap formation. Schibler, U., Perry, R.P. Cell (1976) [Pubmed]
  12. Poly(A) polymerase and a dissociable polyadenylation stimulatory factor encoded by vaccinia virus. Gershon, P.D., Ahn, B.Y., Garfield, M., Moss, B. Cell (1991) [Pubmed]
  13. Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling. Frischknecht, F., Moreau, V., Röttger, S., Gonfloni, S., Reckmann, I., Superti-Furga, G., Way, M. Nature (1999) [Pubmed]
  14. A Tyr/Ser protein phosphatase encoded by vaccinia virus. Guan, K.L., Broyles, S.S., Dixon, J.E. Nature (1991) [Pubmed]
  15. Role of DNA replication in vaccinia virus gene expression: a naked template is required for transcription of three late trans-activator genes. Keck, J.G., Baldick, C.J., Moss, B. Cell (1990) [Pubmed]
  16. Prevention of vaccinia virus infection in immunodeficient mice by vector-directed IL-2 expression. Flexner, C., Hügin, A., Moss, B. Nature (1987) [Pubmed]
  17. T-lymphocyte priming and protection against Friend leukemia by vaccinia-retrovirus env gene recombinant. Earl, P.L., Moss, B., Morrison, R.P., Wehrly, K., Nishio, J., Chesebro, B. Science (1986) [Pubmed]
  18. Protection of cattle against rinderpest with vaccinia virus recombinants expressing the HA or F gene. Yilma, T., Hsu, D., Jones, L., Owens, S., Grubman, M., Mebus, C., Yamanaka, M., Dale, B. Science (1988) [Pubmed]
  19. Analysis of the hemagglutinin glycoprotein from mutants of vaccinia virus that accumulates on the nuclear envelope. Shida, H., Matsumoto, S. Cell (1983) [Pubmed]
  20. Recovery from autoimmunity of MRL/lpr mice after infection with an interleukin-2/vaccinia recombinant virus. Gutierrez-Ramos, J.C., Andreu, J.L., Revilla, Y., Viñuela, E., Martinez, C. Nature (1990) [Pubmed]
  21. CD40 ligand has potent antiviral activity. Ruby, J., Bluethmann, H., Aguet, M., Ramshaw, I.A. Nat. Med. (1995) [Pubmed]
  22. IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. Miki, H., Yamaguchi, H., Suetsugu, S., Takenawa, T. Nature (2000) [Pubmed]
  23. PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. Rohan, P.J., Davis, P., Moskaluk, C.A., Kearns, M., Krutzsch, H., Siebenlist, U., Kelly, K. Science (1993) [Pubmed]
  24. Epidermal growth factor receptor occupancy inhibits vaccinia virus infection. Eppstein, D.A., Marsh, Y.V., Schreiber, A.B., Newman, S.R., Todaro, G.J., Nestor, J.J. Nature (1985) [Pubmed]
  25. Partial impairment of cytokine responses in Tyk2-deficient mice. Karaghiosoff, M., Neubauer, H., Lassnig, C., Kovarik, P., Schindler, H., Pircher, H., McCoy, B., Bogdan, C., Decker, T., Brem, G., Pfeffer, K., Müller, M. Immunity (2000) [Pubmed]
  26. Tyrosine phosphorylation of VHR phosphatase by ZAP-70. Alonso, A., Rahmouni, S., Williams, S., van Stipdonk, M., Jaroszewski, L., Godzik, A., Abraham, R.T., Schoenberger, S.P., Mustelin, T. Nat. Immunol. (2003) [Pubmed]
  27. Effect of nonprotective vaccination on antibody response to subsequent human immunodeficiency virus infection. Pincus, S.H., Messer, K.G., Hu, S.L. J. Clin. Invest. (1994) [Pubmed]
  28. Mapping the active-site tyrosine of vaccinia virus DNA topoisomerase I. Shuman, S., Kane, E.M., Morham, S.G. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  29. Resistance to human immunodeficiency virus 1 infection of SCID mice reconstituted with peripheral blood leukocytes from donors vaccinated with vaccinia gp160 and recombinant gp160. Mosier, D.E., Gulizia, R.J., MacIsaac, P.D., Corey, L., Greenberg, P.D. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  30. Neomycin resistance as a dominant selectable marker for selection and isolation of vaccinia virus recombinants. Franke, C.A., Rice, C.M., Strauss, J.H., Hruby, D.E. Mol. Cell. Biol. (1985) [Pubmed]
  31. Syntaxin 4, VAMP2, and/or VAMP3/cellubrevin are functional target membrane and vesicle SNAP receptors for insulin-stimulated GLUT4 translocation in adipocytes. Olson, A.L., Knight, J.B., Pessin, J.E. Mol. Cell. Biol. (1997) [Pubmed]
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