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Gene Review:

UL48 - transactivates immediate early genes

Bovine herpesvirus 1

Carpenter, D.E. et al., Misra, V. et al.

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Disease relevance of UL48

Sequences of the bovine herpesvirus 1 homologue of herpes simplex virus type-1 alpha-trans-inducing factor (UL48) [1].
A virion protein of herpes simplex virus type-1, called Vmw65, alpha TIF or VP16, interacts with cellular transcription factors to transactivate immediate early viral genes [1].
Like its HSV counterpart, the BHV alpha TIF was synthesized in the later stages of infection and could be demonstrated to be a component of purified virions [2].

High impact information on UL48

In herpes simplex virus (HSV)-infected cells, the transcription of immediate-early (alpha) genes is regulated by a virion component, the alpha gene trans-inducing factor (alpha TIF) [2].
The amino acid sequence of the BHV-1 protein is similar to that of alpha TIF, except in the C-terminal one-third of the protein [1].

References

Sequences of the bovine herpesvirus 1 homologue of herpes simplex virus type-1 alpha-trans-inducing factor (UL48). Carpenter, D.E., Misra, V. Gene (1992) [Pubmed]
Protein and DNA elements involved in transactivation of the promoter of the bovine herpesvirus (BHV) 1 IE-1 transcription unit by the BHV alpha gene trans-inducing factor. Misra, V., Bratanich, A.C., Carpenter, D., O'Hare, P. J. Virol. (1994) [Pubmed]

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