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Gene Review

GSHVgp1  -  core antigen

Ground squirrel hepatitis virus

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Disease relevance of GSHVgp1


High impact information on GSHVgp1

  • All virus strains analysed contained some characteristic differences when compared to genotype A: a translational stop codon at aa 2 and 28 of the preCore region; a 36 nt (12 aa) insert in the amino-terminal part of the Core antigen (HBcAg); a 2 aa deletion in the carboxy-terminal part of HBcAg; and a 1 aa deletion in the preS1 open reading frame [5].


  1. Core antigen-specific immunoglobulin G bound to the liver cell membrane in chronic hepatitis B. Trevisan, A., Realdi, G., Alberti, A., Ongaro, G., Pornaro, E., Meliconi, R. Gastroenterology (1982) [Pubmed]
  2. Core antigen and antibody in woodchucks after infection with woodchuck hepatitis virus. Ponzetto, A., Cote, P.J., Ford, E.C., Purcell, R.H., Gerin, J.L. J. Virol. (1984) [Pubmed]
  3. Determination of immunoglobulin M antibodies for hepatitis B core antigen with a capture enzyme immunoassay and biotin-labeled core antigen produced in Escherichia coli. Vilja, P., Turunen, H.J., Leinikki, P.O. J. Clin. Microbiol. (1985) [Pubmed]
  4. Core antigen and circulating anti-core antibody in hepatitis B infection. Howard, C.R., Zuckerman, A.J. J. Immunol. Methods (1977) [Pubmed]
  5. A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness. Stuyver, L., De Gendt, S., Van Geyt, C., Zoulim, F., Fried, M., Schinazi, R.F., Rossau, R. J. Gen. Virol. (2000) [Pubmed]
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