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Gene Review:

E296R - AP endonuclease class II

African swine fever virus

Redrejo Rodríguez, M., Redrejo-Rodríguez, M. et al.

Modesto Redrejo Rodríguez,

ASFV protein pE296R is a class II AP endonuclease, similar to E. coli Nfo (Endonuclease IV) protein. Using an ASFV deletion mutant lacking the E296R gene, we have determined that the viral AP endonuclease is required for virus growth in macrophages but not in Vero cells [1].

Also, the viral protein pE296R protects against chronic exposure to genotoxic agents, such as MMS or t-BuO₂H [2] to a similar extent than the E. coli Nfo protein [3].

References

African Swine Fever Virus Protein pE296R Is a DNA Repair Apurinic/Apyrimidinic Endonuclease Required for Virus Growth in Swine Macrophages. Redrejo-Rodríguez, M., García-Escudero, R., Yáñez-Muñoz, R.J., Salas, M.L., Salas, J. J. Virol. (2006) [Pubmed]
Contributions of an endonuclease IV homologue to DNA repair in the African swine fever virus. Lamarche, B.J., Tsai, M.D. Biochemistry. (2006) [Pubmed]
African swine fever virus AP endonuclease is a redox-sensitive enzyme that repairs alkylating and oxidative damage to DNA. Redrejo-Rodríguez, M., Ishchenko, A.A., Saparbaev, M.K., Salas, M.L., Salas, J. Virology. (2009) [Pubmed]

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