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Gene Review

ORF2  -  26K triple gene block protein

Foxtail mosaic virus

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Disease relevance of ORF2

  • ORF2, 3, and 4, which form the "triple gene block" characteristic of the potexviruses, encode proteins with molecular mass of 25, 12, and 7 KDa, respectively [1].

High impact information on ORF2

  • The open reading frame 2 (ORF2) of the potexviral genome encodes a 24- to 26-kDa protein which is part of the "triple gene block," a group of overlapping ORFs also present in the genomes of the carla-, hordei-, and furoviruses [2].
  • The amino acid sequences of the homologous ORF2 products encoded by these related viruses suggest that they specify NTP binding and possibly helicase activities [2].
  • The ORF1 protein was found to be highly homologous to the putative potexvirus RNA replicases; ORF2, -3, -5 and -6 proteins also have analogues among the potex- and/or carlavirus-encoded proteins [3].
  • The genome of definitive viral species is made up of five ORFs encoding respectively, the replication-related proteins (ORF 1), the putative movement proteins (ORF 2 to 4, constituting the triple block gene), and the coat protein (ORF 5) [4].

Biological context of ORF2

  • In addition to substitutions, two single-base deletions, one in the intercistronic region between ORF1 and ORF2 and the other in the ORF2, were found on the CymMV-K2 genome [5].


  1. Complete nucleotide sequence and genome organization of a Cactus virus X strain from Hylocereus undatus (Cactaceae). Liou, M.R., Chen, Y.R., Liou, R.F. Arch. Virol. (2004) [Pubmed]
  2. Purification, properties, and subcellular localization of foxtail mosaic potexvirus 26-kDa protein. Rouleau, M., Smith, R.J., Bancroft, J.B., Mackie, G.A. Virology (1994) [Pubmed]
  3. Nucleotide sequence of shallot virus X RNA reveals a 5'-proximal cistron closely related to those of potexviruses and a unique arrangement of the 3'-proximal cistrons. Kanyuka, K.V., Vishnichenko, V.K., Levay, K.E., Kondrikov DYu, n.u.l.l., Ryabov, E.V., Zavriev, S.K. J. Gen. Virol. (1992) [Pubmed]
  4. Foveavirus, a new plant virus genus. Martelli, G.P., Jelkmann, W. Arch. Virol. (1998) [Pubmed]
  5. Genome characterization of a Korean isolate of cymbidium mosaic virus. Kim, J.D., Koo, Y.B., Chang, M.U. Mol. Cells (1998) [Pubmed]
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