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Gene Review

ORF1  -  152K protein

Foxtail mosaic virus

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Disease relevance of ORF1


High impact information on ORF1

  • The N-terminal domain of the viral replicase functions as an mRNA capping enzyme, which exhibits both GTP methyltransferase and S-adenosylmethionine (AdoMet)-dependent guanylyltransferase activities [4].
  • Open reading frame 1 of Bamboo mosaic virus (BaMV), a Potexvirus in the alphavirus-like superfamily, encodes a 155-kDa replicase responsible for the formation of the 5' cap structure and replication of the viral RNA genome [4].
  • Plants transformed with a nucleotide sequence coding for a truncated RNA 2 replicase gene of the subgroup I strain of cucumber mosaic virus, Fny-CMV, are resistant to cucumber mosaic disease [2].


  1. Complete nucleotide sequence and genome organization of a Cactus virus X strain from Hylocereus undatus (Cactaceae). Liou, M.R., Chen, Y.R., Liou, R.F. Arch. Virol. (2004) [Pubmed]
  2. Specificity of replicase-mediated resistance to cucumber mosaic virus. Zaitlin, M., Anderson, J.M., Perry, K.L., Zhang, L., Palukaitis, P. Virology (1994) [Pubmed]
  3. Organization and interviral homologies of the 3'-terminal portion of potato virus S RNA. MacKenzie, D.J., Tremaine, J.H., Stace-Smith, R. J. Gen. Virol. (1989) [Pubmed]
  4. Critical residues for GTP methylation and formation of the covalent m7GMP-enzyme intermediate in the capping enzyme domain of bamboo mosaic virus. Huang, Y.L., Han, Y.T., Chang, Y.T., Hsu, Y.H., Meng, M. J. Virol. (2004) [Pubmed]
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