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Gene Review

H2-M2  -  histocompatibility 2, M region locus 2

Mus musculus

Synonyms: H-2M2, Thy19.4
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High impact information on H2-M2

  • We have determined the genomic sequence of H2-M2 in seven haplotypes from nine inbred strains of mice and in five wild-derived haplotypes [1].
  • Murine MHC class Ib gene, H2-M2, encodes a conserved surface-expressed glycoprotein [1].
  • The genetic length between D17Leh89-D17Mit64 and Pgk2-Aeg can be estimated as 0.5-0.7 centiMorgan (cM), and the most distal class I gene, H2-M2, can be placed 0.3-1.0 cM proximal to the t-inversion breakpoint [2].
  • This report describes a newly identified nonclassical class I gene, Thy19.4, which contains an open reading frame and resembles in several regards the genes encoding classical class I molecules [3].
  • The similarities include shared amino acid sequence motifs which suggest that the putative Thy19.4 molecule may assume a tertiary structure similar to that of the classical class I molecules, as well as widespread transcription in a variety of tissues [3].


  1. Murine MHC class Ib gene, H2-M2, encodes a conserved surface-expressed glycoprotein. Moore, Y.F., Lambracht-Washington, D., Tabaczewski, P., Fischer Lindahl, K. Immunogenetics (2004) [Pubmed]
  2. BAC clones and STS markers near the distal breakpoint of the fourth t-inversion, In(17)4d, in the H2-M region on mouse chromosome 17. Yoshino, M., Xiao, H., Amadou, C., Jones, E.P., Lindahl, K.F. Mamm. Genome (1998) [Pubmed]
  3. Analysis of a new class I gene mapping to the Hmt region of the mouse. Brorson, K.A., Richards, S., Hunt, S.W., Cheroutre, H., Lindahl, K.F., Hood, L. Immunogenetics (1989) [Pubmed]
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