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MeSH Review

Genes, MHC Class I

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Disease relevance of Genes, MHC Class I


High impact information on Genes, MHC Class I

  • The products of certain nonclassical MHC-linked class I genes bind peptides in a similar way [6].
  • M3 is as divergent from classical, antigen-presenting H-2 molecules as from other class I genes of the Hmt and the Qa/Tla regions [7].
  • IRF-1 and IRF-2, which bind to the same cis-elements within the promoters of type I IFN and IFN-inducible MHC class I genes, were identified previously [8].
  • Our findings suggest that the two sequences are derived from allelic class I genes, which are nonpolymorphic, in contrast to H-2K allelic sequences from the same mice, and they may encode liver-specific polypeptides of unknown function [9].
  • A nonpolymorphic class I gene in the murine major histocompatibility complex [9].

Chemical compound and disease context of Genes, MHC Class I


Biological context of Genes, MHC Class I

  • An expressed class I gene, MR1, has now been identified on human chromosome 1q25, outside the MHC [12].
  • Nevertheless, the ability to induce major histocompatibility class I genes following IFN treatment was not impaired in these clones [13].
  • In this study, it is shown that the cis-acting regulatory element site alpha of the MHC class I promoter is essential for the IFN gamma-induced transactivation of MHC class I gene expression through the ISRE [14].
  • Attempts to find rat homologues of the mouse Tla genes by crosshybridization of rat cosmids with a range of different TLa-specific probes were unsuccessful, suggesting that this large group of divergent class I genes is absent or nearly so from the rat [15].
  • The distribution of the pattern of sequence polymorphism in the cat as compared with genetic diversity of human and mouse class I genes provides evidence for four coordinate factors that contribute to the origin and sustenance of abundant allele diversity that characterizes the MHC in the species [16].

Anatomical context of Genes, MHC Class I


Associations of Genes, MHC Class I with chemical compounds


Gene context of Genes, MHC Class I

  • The expressed MHC class I genes of this species are more closely related to the human non-classical HLA-G gene than they are to genes of the human classical HLA-A, -B, and -C loci [26].
  • The third expressed non-A, -B, and -C class I gene, HLA-E, is located between HLA-A and HLA-C (4) [27].
  • The characterization of this unique HLA class I gene and the demonstration of its tissue-specific expression have prompted us to propose that HLA-5.4 be designated HLA-F [28].
  • (iii) Unlike all other known members of the class I gene family, Mill1 and Mill2 have an exon between those coding for the signal peptide and the alpha1 domain [29].
  • Two highly divergent human MHC class I genes, MICA and MICB, are regulated by promoter heat shock elements similar to those of HSP70 genes [30].

Analytical, diagnostic and therapeutic context of Genes, MHC Class I

  • Sequence analysis has revealed that class I genes from the H-2D subregion of the MHC (which includes the D and L genes) differ from the class I gene from the H-2K subregion (the K gene) by the insertion of a type 2 Alu-like repetitive element (the murine B2 sequence) within the 3' noncoding region of the D and L genes [31].
  • Restriction endonuclease mapping of the lambda 3a clone shows that the gene is intact and that, although many restriction sites are conserved, the gene in lambda 3a differs from other class I genes [32].
  • Oligonucleotide arrays for high-throughput SNPs detection in the MHC class I genes: HLA-B as a model system [33].
  • To examine the role of alpha 1 and alpha 2 regions in antibody and CTL recognition, the third exon of H-2Dd, Kd, and Ld transplantation antigen genes was replaced by the homologous coding region of the Qa-2-coded class I gene, Q6 [34].
  • Finally, Southern blot analysis of a number of wild mice and related animals suggests that a gene closely related to the present T10c gene may be the ancestor of this subfamily of class I genes characterized by the presence of an unusual second domain [35].


  1. Mutation detection and typing of polymorphic loci through double-strand conformation analysis. Argüello, J.R., Little, A.M., Pay, A.L., Gallardo, D., Rojas, I., Marsh, S.G., Goldman, J.M., Madrigal, J.A. Nat. Genet. (1998) [Pubmed]
  2. alpha-Interferon-induced transcription of HLA and metallothionein genes containing homologous upstream sequences. Friedman, R.L., Stark, G.R. Nature (1985) [Pubmed]
  3. Immunotherapy of a murine tumor with interleukin 2. Increased sensitivity after MHC class I gene transfection. Weber, J.S., Jay, G., Tanaka, K., Rosenberg, S.A. J. Exp. Med. (1987) [Pubmed]
  4. Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility complex class I. Maldonado, M.A., Eisenberg, R.A., Roper, E., Cohen, P.L., Kotzin, B.L. J. Exp. Med. (1995) [Pubmed]
  5. Induction of antitumor immunity in mice by allo-major histocompatibility complex class I gene transfectant with strong antigen expression. Isobe, K., Hasegawa, Y., Iwamoto, T., Hasegawa, T., Kawashima, K., Ding, L.N., Nakashima, I. J. Natl. Cancer Inst. (1989) [Pubmed]
  6. Mechanisms of MHC class I--restricted antigen processing. Pamer, E., Cresswell, P. Annu. Rev. Immunol. (1998) [Pubmed]
  7. H-2M3 encodes the MHC class I molecule presenting the maternally transmitted antigen of the mouse. Wang, C.R., Loveland, B.E., Lindahl, K.F. Cell (1991) [Pubmed]
  8. Absence of the type I IFN system in EC cells: transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated. Harada, H., Willison, K., Sakakibara, J., Miyamoto, M., Fujita, T., Taniguchi, T. Cell (1990) [Pubmed]
  9. A nonpolymorphic class I gene in the murine major histocompatibility complex. Mellor, A.L., Weiss, E.H., Kress, M., Jay, G., Flavell, R.A. Cell (1984) [Pubmed]
  10. Oxidative stress induces the expression of the major histocompatibility complex in murine tumor cells. Oliva, M.R., Iradi, A., Garrido, F., Ramos, M., Oltra, A.M., Muñiz, P., Sáez, G.T. Free Radic. Res. (2001) [Pubmed]
  11. The effect of ethanol on the expression of HLA class I genes in human colon adenocarcinoma cell lines. Papavassiliou, E.D., Arvind, P., Tsioulias, G.J., Qiao, L., Goldin, E., Staiano-Coico, L., Rigas, B. Cancer Lett. (1994) [Pubmed]
  12. A gene outside the human MHC related to classical HLA class I genes. Hashimoto, K., Hirai, M., Kurosawa, Y. Science (1995) [Pubmed]
  13. Constitutive expression of c-fos antisense RNA blocks c-fos gene induction by interferon and by phorbol ester and reduces c-myc expression in F9 embryonal carcinoma cells. Levi, B.Z., Ozato, K. Genes Dev. (1988) [Pubmed]
  14. Site alpha is crucial for two routes of IFN gamma-induced MHC class I transactivation: the ISRE-mediated route and a novel pathway involving CIITA. Gobin, S.J., Peijnenburg, A., Keijsers, V., van den Elsen, P.J. Immunity (1997) [Pubmed]
  15. Cloning and expression of class I major histocompatibility complex genes of the rat. Jameson, S.C., Tope, W.D., Tredgett, E.M., Windle, J.M., Diamond, A.G., Howard, J.C. J. Exp. Med. (1992) [Pubmed]
  16. DNA recombination and natural selection pressure sustain genetic sequence diversity of the feline MHC class I genes. Yuhki, N., O'Brien, S.J. J. Exp. Med. (1990) [Pubmed]
  17. Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11. Schust, D.J., Tortorella, D., Seebach, J., Phan, C., Ploegh, H.L. J. Exp. Med. (1998) [Pubmed]
  18. Transcriptional regulation of antigen presentation. van den Elsen, P.J., Holling, T.M., Kuipers, H.F., van der Stoep, N. Curr. Opin. Immunol. (2004) [Pubmed]
  19. Somatic variation of H-2Kk expression and structure in a T-cell lymphoma: instability, stabilization, high production and structural mutation. Holtkamp, B., Cramer, M., Rajewsky, K. EMBO J. (1983) [Pubmed]
  20. Autoregulation of thyroid-specific gene transcription by thyroglobulin. Suzuki, K., Lavaroni, S., Mori, A., Ohta, M., Saito, J., Pietrarelli, M., Singer, D.S., Kimura, S., Katoh, R., Kawaoi, A., Kohn, L.D. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  21. Role for major histocompatibility complex class I in regulating natural killer cell-mediated killing of virus-infected cells. Kaufman, D.S., Schoon, R.A., Leibson, P.J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  22. Negative regulation of the major histocompatibility complex class I promoter in embryonal carcinoma cells. Flanagan, J.R., Murata, M., Burke, P.A., Shirayoshi, Y., Appella, E., Sharp, P.A., Ozato, K. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  23. Developmental and tissue-specific regulation of the Q10 class I gene by DNA methylation. Tanaka, K., Barra, Y., Isselbacher, K.J., Khoury, G., Jay, G. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  24. Intron sequences reveal evolutionary relationships among major histocompatibility complex class I genes. Ronne, H., Widmark, E., Rask, L., Peterson, P.A. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  25. H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element. Hamada, K., Gleason, S.L., Levi, B.Z., Hirschfeld, S., Appella, E., Ozato, K. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  26. Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes. Watkins, D.I., Chen, Z.W., Hughes, A.L., Evans, M.G., Tedder, T.F., Letvin, N.L. Nature (1990) [Pubmed]
  27. Chromosomal organization of the human major histocompatibility complex class I gene family. Koller, B.H., Geraghty, D.E., DeMars, R., Duvick, L., Rich, S.S., Orr, H.T. J. Exp. Med. (1989) [Pubmed]
  28. Human leukocyte antigen F (HLA-F). An expressed HLA gene composed of a class I coding sequence linked to a novel transcribed repetitive element. Geraghty, D.E., Wei, X.H., Orr, H.T., Koller, B.H. J. Exp. Med. (1990) [Pubmed]
  29. A family of MHC class I-like genes located in the vicinity of the mouse leukocyte receptor complex. Kasahara, M., Watanabe, Y., Sumasu, M., Nagata, T. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  30. Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Groh, V., Bahram, S., Bauer, S., Herman, A., Beauchamp, M., Spies, T. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  31. Functional insertion of an Alu type 2 (B2 SINE) repetitive sequence in murine class I genes. Kress, M., Barra, Y., Seidman, J.G., Khoury, G., Jay, G. Science (1984) [Pubmed]
  32. Expression in L cells of transfected class I genes from the mouse major histocompatibility complex. Schepart, B.S., Woodward, J.G., Palmer, M.J., Macchi, M.J., Basta, P., McLaughlin-Taylor, E., Frelinger, J.A. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  33. Oligonucleotide arrays for high-throughput SNPs detection in the MHC class I genes: HLA-B as a model system. Guo, Z., Gatterman, M.S., Hood, L., Hansen, J.A., Petersdorf, E.W. Genome Res. (2002) [Pubmed]
  34. Interaction of alpha 1 with alpha 2 region in class I MHC proteins contributes determinants recognized by antibodies and cytotoxic T cells. Stroynowski, I., Clark, S., Henderson, L.A., Hood, L., McMillan, M., Forman, J. J. Immunol. (1985) [Pubmed]
  35. Comparative structure of two duplicated T1a class I genes (T10c and 37) of the murine H-2d MHC. Implications on the evolution of the T1a region. Nakayama, K., Tokito, S., Jaulin, C., Delarbre, C., Kourilsky, P., Nakauchi, H., Gachelin, G. J. Immunol. (1990) [Pubmed]
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