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Gene Review

FCVgp1  -  polyprotein

Feline calicivirus

 
 
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Disease relevance of FCVgp1

  • Feline calicivirus (FCV) nonstructural proteins are translated as part of a large polyprotein that undergoes autocatalytic processing by the virus-encoded 3C-like proteinase [1].
  • Feline calicivirus (FCV), a member of the Caliciviridae, produces its major structural protein as a precursor polyprotein from a subgenomic-sized mRNA [2].
  • In vitro mapping studies of the MD145 norovirus (Caliciviridae) ORF1 polyprotein identified two stable cleavage products containing the viral RNA-dependent RNA polymerase (RdRp) domains: ProPol (a precursor comprised of both the proteinase and polymerase) and Pol (the mature polymerase) [3].
  • ORF1 encoded a polyprotein (calculated Mr of 214,802) which had the conserved motifs of non-structural proteins of other caliciviruses and picornaviruses [4].
  • Despite these diverse origins, comparisons between all strains showed a similar degree of sequence variation within both ORF1 (non-structural polyprotein) and ORF2 (major capsid protein) (amino acid distances of 7.7-13.0% and 8.8-18.6%, respectively) [5].
 

High impact information on FCVgp1

  • Processing map and essential cleavage sites of the nonstructural polyprotein encoded by ORF1 of the feline calicivirus genome [1].
  • In this study, we mapped three new cleavage sites (E(46)/A(47), E(331)/D(332), and E(685)/N(686)) recognized by the virus proteinase in the N-terminal part of the open reading frame 1 (ORF1) polyprotein to complete the processing map [1].

References

  1. Processing map and essential cleavage sites of the nonstructural polyprotein encoded by ORF1 of the feline calicivirus genome. Sosnovtsev, S.V., Garfield, M., Green, K.Y. J. Virol. (2002) [Pubmed]
  2. Cleavage of the feline calicivirus capsid precursor is mediated by a virus-encoded proteinase. Sosnovtsev, S.V., Sosnovtseva, S.A., Green, K.Y. J. Virol. (1998) [Pubmed]
  3. Norovirus proteinase-polymerase and polymerase are both active forms of RNA-dependent RNA polymerase. Belliot, G., Sosnovtsev, S.V., Chang, K.O., Babu, V., Uche, U., Arnold, J.J., Cameron, C.E., Green, K.Y. J. Virol. (2005) [Pubmed]
  4. Complete nucleotide sequence, genome organization and phylogenic analysis of the canine calicivirus. Matsuura, Y., Tohya, Y., Nakamura, K., Shimojima, M., Roerink, F., Mochizuki, M., Takase, K., Akashi, H., Sugimura, T. Virus Genes (2002) [Pubmed]
  5. Nucleotide sequence of UK and Australian isolates of feline calicivirus (FCV) and phylogenetic analysis of FCVs. Glenn, M., Radford, A.D., Turner, P.C., Carter, M., Lowery, D., DeSilver, D.A., Meanger, J., Baulch-Brown, C., Bennett, M., Gaskell, R.M. Vet. Microbiol. (1999) [Pubmed]
 
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