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Gene Review

Hars  -  histidyl-tRNA synthetase

Mus musculus

Synonyms: HisRS, Histidine--tRNA ligase, cytoplasmic, Histidyl-tRNA synthetase, MMHRS
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High impact information on Hars

  • The disease is inflammatory, limited to skeletal muscles, self-sustaining, more severe in females, and often accompanied by autoantibodies, including, in some mice, autoantibodies to histidyl-tRNA synthetase, the most common specificity found in the spontaneous human disease, anti-Jo-1 [1].
  • Mouse GCN2 expressed in yeast was found to inhibit growth by hyperphosphorylation of eIF-2alpha, requiring both the kinase catalytic domain and the HisRS-related sequences [2].
  • Like their yeast counterpart, the mouse GCN2 isoforms contain HisRS-related sequences juxtaposed to the kinase catalytic domain [2].
  • Our results show that mortalin and HisRS genes, which map closely to the Egr1 locus, have conserved the 129/Sv haplotype despite numerous back-crossing of the null mice progeny with C57Bl/6J animals [3].
  • Finally, we report the identification of new isoforms of HisRS and mortalin (mot-3) encoded by the 129/Sv haplotype [3].


  1. Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies. Nagaraju, K., Raben, N., Loeffler, L., Parker, T., Rochon, P.J., Lee, E., Danning, C., Wada, R., Thompson, C., Bahtiyar, G., Craft, J., Hooft Van Huijsduijnen, R., Plotz, P. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha. Sood, R., Porter, A.C., Olsen, D.A., Cavener, D.R., Wek, R.C. Genetics (2000) [Pubmed]
  3. New mortalin and histidyl tRNA synthetase isoforms point out a pitfall in proteomic analysis of Egr1 genetically modified mice. Chardonnet, S., Decottignies, P., Amar, L., Le Caer, J.P., Davis, S., Laroche, S., Le Mar??chal, P. Proteomics (2007) [Pubmed]
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