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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Hsd17b3  -  hydroxysteroid (17-beta) dehydrogenase 3

Mus musculus

Synonyms: 17(beta)HSD type 3, 17-beta-HSD 3, 17-beta-hydroxysteroid dehydrogenase type 3, Edh17b3, Testicular 17-beta-hydroxysteroid dehydrogenase, ...
 
 
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High impact information on Hsd17b3

  • Elevated plasma testosterone in alphaERKO and alphabetaERKO females was attributable to aberrant expression of Hsd17b3 in the ovary, representing a form of endocrine sex reversal, as this enzyme is unique to the testes [1].
  • These data indicate that intraovarian ERalpha actions are required to repress Hsd17b3 expression in the ovary and may be important to maintaining a female phenotype in SI/TI cells [2].
 

Biological context of Hsd17b3

  • In turn, ectopic expression of the Leydig cell-specific enzyme, Hsd17b3, and male-like testosterone synthesis in the alphaERKO ovary are unique to this genotype and are therefore the culmination of elevated LH and the loss of functional ERalpha within the ovary [3].
 

Associations of Hsd17b3 with chemical compounds

  • ERalpha-null (alphaERKO) female mice exhibit testis-like levels of Hsd17b3 expression in the ovaries and male-like levels of plasma T [2].

References

  1. Characterization of the hypothalamic-pituitary-gonadal axis in estrogen receptor (ER) Null mice reveals hypergonadism and endocrine sex reversal in females lacking ERalpha but not ERbeta. Couse, J.F., Yates, M.M., Walker, V.R., Korach, K.S. Mol. Endocrinol. (2003) [Pubmed]
  2. The intraovarian actions of estrogen receptor-alpha are necessary to repress the formation of morphological and functional Leydig-like cells in the female gonad. Couse, J.F., Yates, M.M., Rodriguez, K.F., Johnson, J.A., Poirier, D., Korach, K.S. Endocrinology (2006) [Pubmed]
  3. Formation of cystic ovarian follicles associated with elevated luteinizing hormone requires estrogen receptor-beta. Couse, J.F., Yates, M.M., Sanford, R., Nyska, A., Nilson, J.H., Korach, K.S. Endocrinology (2004) [Pubmed]
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