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Gene Review

Hsd17b3  -  hydroxysteroid (17-beta) dehydrogenase 3

Mus musculus

Synonyms: 17(beta)HSD type 3, 17-beta-HSD 3, 17-beta-hydroxysteroid dehydrogenase type 3, Edh17b3, Testicular 17-beta-hydroxysteroid dehydrogenase, ...
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High impact information on Hsd17b3

  • Elevated plasma testosterone in alphaERKO and alphabetaERKO females was attributable to aberrant expression of Hsd17b3 in the ovary, representing a form of endocrine sex reversal, as this enzyme is unique to the testes [1].
  • These data indicate that intraovarian ERalpha actions are required to repress Hsd17b3 expression in the ovary and may be important to maintaining a female phenotype in SI/TI cells [2].

Biological context of Hsd17b3

  • In turn, ectopic expression of the Leydig cell-specific enzyme, Hsd17b3, and male-like testosterone synthesis in the alphaERKO ovary are unique to this genotype and are therefore the culmination of elevated LH and the loss of functional ERalpha within the ovary [3].

Associations of Hsd17b3 with chemical compounds

  • ERalpha-null (alphaERKO) female mice exhibit testis-like levels of Hsd17b3 expression in the ovaries and male-like levels of plasma T [2].


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