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Gene Review:

FMR1NB - fragile X mental retardation 1 neighbor

Homo sapiens

Synonyms: CT37, Cancer/testis antigen 37, FLJ25736, Fragile X mental retardation 1 neighbor protein, NY-SAR-35, ...

Lee, S.Y. et al.

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Disease relevance of FMR1NB

In addition to testis-restricted expression, NY-SAR-35 mRNA was expressed in sarcoma, melanoma, esophageal cancer, lung cancer and breast cancer [1].

High impact information on FMR1NB

A novel CT antigen, NY-SAR-35, mapping to chromosome Xq28 was identified among the cancer-related antigens, and encodes a putative extracellular protein [1].

Analytical, diagnostic and therapeutic context of FMR1NB

NY-SAR-35 is therefore a potential target for cancer vaccines and monoclonal antibody-based immunotherapies [1].

References

Immunomic analysis of human sarcoma. Lee, S.Y., Obata, Y., Yoshida, M., Stockert, E., Williamson, B., Jungbluth, A.A., Chen, Y.T., Old, L.J., Scanlan, M.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]

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