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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

AWAT1  -  acyl-CoA wax alcohol acyltransferase 1

Homo sapiens

Synonyms: Acyl-CoA wax alcohol acyltransferase 1, DGA2, DGAT2L3, Diacylglycerol O-acyltransferase 2-like protein 3, Diacylglycerol acyltransferase 2, ...
 
 
 
 
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High impact information on DGAT2L3

  • All four gene products mediate the synthesis of triacylglycerol; however, two of the X-linked genes act as acyl-CoA wax alcohol acyltransferases (AWAT 1 and 2) that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters [1].
  • In situ hybridizations demonstrate a differentiation-specific expression pattern within the human sebaceous gland for the two AWAT genes, consistent with a significant role in the composition of sebum [1].

References

  1. Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily. Turkish, A.R., Henneberry, A.L., Cromley, D., Padamsee, M., Oelkers, P., Bazzi, H., Christiano, A.M., Billheimer, J.T., Sturley, S.L. J. Biol. Chem. (2005) [Pubmed]
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