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MeSH Review

Sebaceous Glands

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Disease relevance of Sebaceous Glands


Psychiatry related information on Sebaceous Glands

  • Regardless of SNJ's occurrence as either an isolated lesion or as the fully developed syndrome, including mental retardation and epilepsy, this congenital malformation of the skin, its hair, and sebaceous glands presents rare and histologically intriguing problems for the practitioner [6].

High impact information on Sebaceous Glands


Chemical compound and disease context of Sebaceous Glands


Biological context of Sebaceous Glands


Anatomical context of Sebaceous Glands


Associations of Sebaceous Glands with chemical compounds

  • Values of f were lower on skin areas rich in sebaceous glands (0.29-0.46 on forehead) than on areas poor in these glands (0.41-0.70 for forearms; 0.60 on feet) and lower for esterified (0.27-0.33) than for free (0.39-0.48) cholesterol [11].
  • In the androgen-treated group, sebaceous gland volume (micron 3 X 10(-3) increased from 896 +/- 194 to 3,233 +/- 754 (P less than 0.001), sebaceous cell area (micron 2) increased from 167 +/- 12 to 243 +/- 19 (P less than 0.001), and labeling index (percentage) increased from 2.7 +/- 0.7 to 6.4 +/- 0.9 (P less than 0.01) [27].
  • A close correlation was found between the carcinogenicities and destructive activities of nitrofuran derivatives on the sebaceous glands [28].
  • Specific carcinogenic effect of N-methyl-N-nitrosourea on the midventral sebaceous gland of the gerbil (Meriones unguiculatus) [29].
  • Under similar conditions, the potent carcinogen 7,12-dimethylbenz(alpha)athracene almost completely destroyed the sebaceous glands at a dose of 0.05 mg/mouse, but dimethyl sulfoxide (used as solvent for the test compounds) had no effect [28].

Gene context of Sebaceous Glands


Analytical, diagnostic and therapeutic context of Sebaceous Glands


  1. Constitutive expression of erbB2 in epidermis of transgenic mice results in epidermal hyperproliferation and spontaneous skin tumor development. Kiguchi, K., Bol, D., Carbajal, S., Beltrán, L., Moats, S., Chan, K., Jorcano, J., DiGiovanni, J. Oncogene (2000) [Pubmed]
  2. The skin produces urocortin. Slominski, A., Roloff, B., Curry, J., Dahiya, M., Szczesniewski, A., Wortsman, J. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  3. Glutathione, glutathione S-transferase and reactive oxygen species of human scalp sebaceous glands in male pattern baldness. Giralt, M., Cervello, I., Nogues, M.R., Puerto, A.M., Ortin, F., Argany, N., Mallol, J. J. Invest. Dermatol. (1996) [Pubmed]
  4. Topical ALA-photodynamic therapy for the treatment of acne vulgaris. Hongcharu, W., Taylor, C.R., Chang, Y., Aghassi, D., Suthamjariya, K., Anderson, R.R. J. Invest. Dermatol. (2000) [Pubmed]
  5. Histologic changes produced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the skin of mice carrying mutations that affect the integument. Poland, A., Knutson, J.C., Glover, E. J. Invest. Dermatol. (1984) [Pubmed]
  6. Nevus sebaceus of Jadassohn: the head and neck manifestations. Hagan, W.E. Laryngoscope (1987) [Pubmed]
  7. Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse. Zheng, Y., Eilertsen, K.J., Ge, L., Zhang, L., Sundberg, J.P., Prouty, S.M., Stenn, K.S., Parimoo, S. Nat. Genet. (1999) [Pubmed]
  8. Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides. Chen, W., Kelly, M.A., Opitz-Araya, X., Thomas, R.E., Low, M.J., Cone, R.D. Cell (1997) [Pubmed]
  9. Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid. Peck, G.L., Olsen, T.G., Yoder, F.W., Strauss, J.S., Downing, D.T., Pandya, M., Butkus, D., Arnaud-Battandier, J. N. Engl. J. Med. (1979) [Pubmed]
  10. Stimulation of all epithelial elements during skin regeneration by keratinocyte growth factor. Pierce, G.F., Yanagihara, D., Klopchin, K., Danilenko, D.M., Hsu, E., Kenney, W.C., Morris, C.F. J. Exp. Med. (1994) [Pubmed]
  11. Isotope kinetics of human skin cholesterol secretion. Nikkari, T., Schreibman, P.H., Ahrens, E.H. J. Exp. Med. (1975) [Pubmed]
  12. An acne-free naevus. Cunliffe, W.J., Ead, R.D., Perera, W.H., Hodgins, M.B. Br. J. Dermatol. (1977) [Pubmed]
  13. Inhibition of dihydrotestosterone-mediated hamster sebaceous gland hypertrophy by progesterone. Foreman, M.I., Devitt, H., Clanachan, I. Br. J. Dermatol. (1984) [Pubmed]
  14. Exclusive androgenic effect of dehydroepiandrosterone in sebaceous glands of rat skin. Sourla, A., Richard, V., Labrie, F., Labrie, C. J. Endocrinol. (2000) [Pubmed]
  15. Multiple keratoacanthomas associated with steatocystoma multiplex and rheumatoid arthritis. A case report. Sohn, D., Chin, T.C., Fellner, M.J. Archives of dermatology. (1980) [Pubmed]
  16. Sebaceous glands changes following topical application of citral. Abramovici, A., Wolf, R., Sandbank, M. Acta Derm. Venereol. (1983) [Pubmed]
  17. Organ maintenance of human sebaceous glands: in vitro effects of 13-cis retinoic acid and testosterone. Ridden, J., Ferguson, D., Kealey, T. J. Cell. Sci. (1990) [Pubmed]
  18. Analysis of lipid composition of isolated human sebaceous gland homogenates after incubation with cutaneous bacteria. Thin-layer chromatography. Puhvel, S.M., Reisner, R.M., Sakamoto, M. J. Invest. Dermatol. (1975) [Pubmed]
  19. Effect of aging on sebaceous gland activity and on the fatty acid composition of wax esters. Yamamoto, A., Serizawa, S., Ito, M., Sato, Y. J. Invest. Dermatol. (1987) [Pubmed]
  20. The melanocortin 5 receptor is expressed in human sebaceous glands and rat preputial cells. Thiboutot, D., Sivarajah, A., Gilliland, K., Cong, Z., Clawson, G. J. Invest. Dermatol. (2000) [Pubmed]
  21. Expression of the apolipoprotein E gene in the skin is controlled by a unique downstream enhancer. Grehan, S., Allan, C., Tse, E., Walker, D., Taylor, J.M. J. Invest. Dermatol. (2001) [Pubmed]
  22. Nestin expression in hair follicle sheath progenitor cells. Li, L., Mignone, J., Yang, M., Matic, M., Penman, S., Enikolopov, G., Hoffman, R.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  23. Heterogeneous nuclear expression of the promyelocytic leukemia (PML) protein in normal and neoplastic human tissues. Gambacorta, M., Flenghi, L., Fagioli, M., Pileri, S., Leoncini, L., Bigerna, B., Pacini, R., Tanci, L.N., Pasqualucci, L., Ascani, S., Mencarelli, A., Liso, A., Pelicci, P.G., Falini, B. Am. J. Pathol. (1996) [Pubmed]
  24. Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia. Yagyu, H., Kitamine, T., Osuga, J., Tozawa, R., Chen, Z., Kaji, Y., Oka, T., Perrey, S., Tamura, Y., Ohashi, K., Okazaki, H., Yahagi, N., Shionoiri, F., Iizuka, Y., Harada, K., Shimano, H., Yamashita, H., Gotoda, T., Yamada, N., Ishibashi, S. J. Biol. Chem. (2000) [Pubmed]
  25. Skin lipids: an update. Downing, D.T., Stewart, M.E., Wertz, P.W., Colton, S.W., Abraham, W., Strauss, J.S. J. Invest. Dermatol. (1987) [Pubmed]
  26. Expression of diazepam-binding inhibitor peptide in human skin: an immunohistochemical and ultrastructural study. Alho, H., Vaalasti, A., Podkletnova, I., Rechardt, L. J. Invest. Dermatol. (1993) [Pubmed]
  27. Development of a nude mouse model to study human sebaceous gland physiology and pathophysiology. Petersen, M.J., Zone, J.J., Krueger, G.G. J. Clin. Invest. (1984) [Pubmed]
  28. Correlation between the carcinogenicities of nitrofuran derivatives and their destructive actions on sebaceous glands of mouse skin. Takizawa, H., Hozumi, M., Sugimura, T., Bryan, G.T. J. Natl. Cancer Inst. (1975) [Pubmed]
  29. Specific carcinogenic effect of N-methyl-N-nitrosourea on the midventral sebaceous gland of the gerbil (Meriones unguiculatus). Haas, H., Hilfrich, J., Kmoch, N., Mohr, U. J. Natl. Cancer Inst. (1975) [Pubmed]
  30. ERV3 and related sequences in humans: structure and RNA expression. Andersson, A.C., Yun, Z., Sperber, G.O., Larsson, E., Blomberg, J. J. Virol. (2005) [Pubmed]
  31. Glycoproteins of the carcinoembryonic antigen (CEA) family are expressed in sweat and sebaceous glands of human fetal and adult skin. Metze, D., Bhardwaj, R., Amann, U., Eades-Perner, A.M., Neumaier, M., Wagener, C., Jantscheff, P., Grunert, F., Luger, T.A. J. Invest. Dermatol. (1996) [Pubmed]
  32. Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity. Ge, L., Gordon, J.S., Hsuan, C., Stenn, K., Prouty, S.M. J. Invest. Dermatol. (2003) [Pubmed]
  33. Progressive hair loss and myocardial degeneration in rough coat mice: reduced lysyl oxidase-like (LOXL) in the skin and heart. Hayashi, K., Cao, T., Passmore, H., Jourdan-Le Saux, C., Fogelgren, B., Khan, S., Hornstra, I., Kim, Y., Hayashi, M., Csiszar, K. J. Invest. Dermatol. (2004) [Pubmed]
  34. 5-Lipoxygenase expression in Langerhans cells of normal human epidermis. Spanbroek, R., Stark, H.J., Janssen-Timmen, U., Kraft, S., Hildner, M., Andl, T., Bosch, F.X., Fusenig, N.E., Bieber, T., Rådmark, O., Samuelsson, B., Habenicht, A.J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  35. Transection level dictates the pattern of hair follicle sheath growth in vitro. Williams, D., Stenn, K.S. Dev. Biol. (1994) [Pubmed]
  36. Local and systemic reduction by topical finasteride or flutamide of hamster flank organ size and enzyme activity. Chen, C., Puy, L.A., Simard, J., Li, X., Singh, S.M., Labrie, F. J. Invest. Dermatol. (1995) [Pubmed]
  37. Influence of photoperiodism on testicular function and sebaceous glands in Syrian hamster. Luderschmidt, C., Hoffmann, K., Bidlingmaier, F. J. Invest. Dermatol. (1984) [Pubmed]
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