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Gene Review:

TCEB3C - transcription elongation factor B...

Homo sapiens

Synonyms: EloA3, Elongin-A3, HsT829, RNA polymerase II transcription factor SIII subunit A3, TCEB3L2, ...

Yamazaki, K. et al., Strichman-Almashanu, L.Z. et al.

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High impact information on TCEB3C

At least two gDMRs mapped near imprinted genes, HYMA1 and a novel homolog of Elongin A and Elongin A2, which we term Elongin A3 [1].
Mechanistic studies have demonstrated that Elongin A3 possesses similar biochemical features to Elongin A2 [2].

Other interactions of TCEB3C

Structure-function analyses using fusion proteins composed of Elongin A3 and Elongin A revealed that the COOH-terminal region of Elongin A is important for the activation by Elongin BC [2].

Analytical, diagnostic and therapeutic context of TCEB3C

Here, we report on the molecular cloning, expression, and biochemical characterization of human Elongin A3, a novel transcription elongation factor that exhibits 49 and 81% identity to Elongin A and the recently identified Elongin A2, respectively [2].

References

A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes. Strichman-Almashanu, L.Z., Lee, R.S., Onyango, P.O., Perlman, E., Flam, F., Frieman, M.B., Feinberg, A.P. Genome Res. (2002) [Pubmed]
Identification and biochemical characterization of a novel transcription elongation factor, Elongin A3. Yamazaki, K., Guo, L., Sugahara, K., Zhang, C., Enzan, H., Nakabeppu, Y., Kitajima, S., Aso, T. J. Biol. Chem. (2002) [Pubmed]

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