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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TCEB3B  -  transcription elongation factor B...

Homo sapiens

Synonyms: ELOA2, EloA2, Elongin-A2, HsT832, RNA polymerase II transcription factor SIII subunit A2, ...
 
 
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High impact information on TCEB3B

  • Mechanistic studies have demonstrated that Elongin A3 possesses similar biochemical features to Elongin A2 [1].
  • Here, we report on the cloning, expression, and characterization of human Elongin A2, a novel transcription elongation factor that exhibited 47% identity and 61% similarity to Elongin A [2].
  • Northern blot analysis revealed that Elongin A2 mRNA was specifically expressed in the testis, suggesting that Elongin A2 may regulate the transcription of testis-specific genes [2].
  • Biochemical studies have shown that Elongin A2 stimulates the rate of transcription elongation by RNA polymerase II and is capable of forming a stable complex with Elongin BC [2].
 

Anatomical context of TCEB3B

  • Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis [2].
 

Analytical, diagnostic and therapeutic context of TCEB3B

  • Here, we report on the molecular cloning, expression, and biochemical characterization of human Elongin A3, a novel transcription elongation factor that exhibits 49 and 81% identity to Elongin A and the recently identified Elongin A2, respectively [1].

References

  1. Identification and biochemical characterization of a novel transcription elongation factor, Elongin A3. Yamazaki, K., Guo, L., Sugahara, K., Zhang, C., Enzan, H., Nakabeppu, Y., Kitajima, S., Aso, T. J. Biol. Chem. (2002) [Pubmed]
  2. Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis. Aso, T., Yamazaki, K., Amimoto, K., Kuroiwa, A., Higashi, H., Matsuda, Y., Kitajima, S., Hatakeyama, M. J. Biol. Chem. (2000) [Pubmed]
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