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Gene Review

SASS6  -  spindle assembly 6 homolog (C. elegans)

Homo sapiens

Synonyms: DKFZp761A078, FLJ22097, HsSAS-6, SAS-6, SAS6, ...
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High impact information on SASS6

  • GFP-HsSAS-6 localizes to centrosomes and its overexpression results in excess foci-bearing centriolar markers [1].
  • Here, we identify SAS-6 as a component that is required for daughter centriole formation in C. elegans [1].

Analytical, diagnostic and therapeutic context of SASS6


  1. SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells. Leidel, S., Delattre, M., Cerutti, L., Baumer, K., Gönczy, P. Nat. Cell Biol. (2005) [Pubmed]
  2. Centriole assembly requires both centriolar and pericentriolar material proteins. Dammermann, A., Müller-Reichert, T., Pelletier, L., Habermann, B., Desai, A., Oegema, K. Dev. Cell (2004) [Pubmed]
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