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Gene Review:

SASS6 - spindle assembly 6 homolog (C. elegans)

Homo sapiens

Synonyms: DKFZp761A078, FLJ22097, HsSAS-6, SAS-6, SAS6, ...

Leidel, S. et al., Dammermann, A. et al.

Dammermann, Müller-Reichert, Pelletier, Habermann, Desai, Oegema,

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High impact information on SASS6

GFP-HsSAS-6 localizes to centrosomes and its overexpression results in excess foci-bearing centriolar markers [1].
Here, we identify SAS-6 as a component that is required for daughter centriole formation in C. elegans [1].

Analytical, diagnostic and therapeutic context of SASS6

We show that SAS-6, a member of a conserved metazoan protein family, is specifically required for new centriole assembly, a result we confirm by electron microscopy [2].

References

SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells. Leidel, S., Delattre, M., Cerutti, L., Baumer, K., Gönczy, P. Nat. Cell Biol. (2005) [Pubmed]
Centriole assembly requires both centriolar and pericentriolar material proteins. Dammermann, A., Müller-Reichert, T., Pelletier, L., Habermann, B., Desai, A., Oegema, K. Dev. Cell (2004) [Pubmed]

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