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Gene Review

ADAMTS15  -  ADAM metallopeptidase with thrombospondin...

Homo sapiens

Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 15, ADAM-TS 15, ADAM-TS15, ADAMTS-15
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High impact information on ADAMTS15

  • For both RFS and OS, the group with high ADAMTS8 and low ADAMTS15 expression had a particularly poor prognosis [1].
  • Differences in basal expression and the magnitude of induction were observed, whilst there was no significant modulation of TIMP-2, -3, RECK, or ADAMTS-15 gene expression [2].


  1. ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma. Porter, S., Span, P.N., Sweep, F.C., Tjan-Heijnen, V.C., Pennington, C.J., Pedersen, T.X., Johnsen, M., Lund, L.R., Rømer, J., Edwards, D.R. Int. J. Cancer (2006) [Pubmed]
  2. Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis. Milner, J.M., Rowan, A.D., Cawston, T.E., Young, D.A. Arthritis Res. Ther. (2006) [Pubmed]
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