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Gene Review

Acot3  -  acyl-CoA thioesterase 3

Mus musculus

Synonyms: AW108394, Acyl-CoA thioesterase 3, Acyl-coenzyme A thioesterase 3, PTE-Ia, Peroxisomal acyl-coenzyme A thioester hydrolase 2a, ...
 
 
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High impact information on Acot3

  • Tissue expression studies revealed that PTE-Ia is highly expressed in kidney, whereas PTE-Ic is most highly expressed in spleen, brain, testis, and proximal and distal intestine [1].
  • Localization experiments using green fluorescent fusion protein showed PTE-Ia and PTE-Ic to be localized in peroxisomes [1].
  • The nomenclature for these genes has tentatively been assigned as CTE-I (cytosolic), MTE-I (mitochondrial), and PTE-Ia and Ib (peroxisomal), based on the identification of putative targeting signals [2].
 

Biological context of Acot3

 

Associations of Acot3 with chemical compounds

  • Lack of regulation of enzyme activity by free CoASH suggests that PTE-Ia and PTE-Ic regulate intraperoxisomal levels of acyl-CoA, and they may have a function in termination of beta-oxidation of fatty acids of different chain lengths [1].

References

 
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