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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gp2  -  glycoprotein 2 (zymogen granule membrane)

Rattus norvegicus

Synonyms: Glycoprotein 80, Pancreatic secretory granule membrane major glycoprotein GP2, Pancreatic zymogen granule membrane protein GP-2, gp80
 
 
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High impact information on Gp2

  • The pattern of glycoprotein secretion is similar to that seen with NGF, although Gp2 (Mr 78,000) is more abundant [1].
  • Altered flux was evidenced by a markedly reduced rate of labeling of lysosomes and a slightly increased rate of labeling of both total membrane proteins of the plasma membrane and of a specific membrane glycoprotein GP80 [2].
  • Turnover half-lives of L-fucose were measured in regenerating liver by pulse-chase experiments in five plasma membrane glycoproteins (Mr 60,000 (gp60), 80,000 (gp80), 120,000 (gp120), 140,000 (gp140), and 160,000 (gp160) [3].
 

Biological context of Gp2

  • Relative to the half-life of the protein backbone the half-live of L-fucose was increased in the five membrane glycoproteins by 70% (gp60), 150% (gp80), 182% (gp120), 60% (gp140) and 16% (gp160) during liver regeneration when compared to normal liver [3].

References

  1. Nerve growth factor and gangliosides stimulate the release of glycoproteins from PC12 pheochromocytoma cells. Yavin, E., Hama, T., Gil, S., Guroff, G. J. Neurochem. (1986) [Pubmed]
  2. Vitamin A excess alters membrane flow in rat liver. Morré, D.M., Morré, D.J., Bowen, S., Reutter, W., Windel, K. Eur. J. Cell Biol. (1988) [Pubmed]
  3. Decreased intramolecular turnover of L-fucose in membrane glycoproteins of rat liver during liver regeneration. Tauber, R., Kronenberger, C., Reutter, W. Biol. Chem. Hoppe-Seyler (1989) [Pubmed]
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