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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Mom2  -  modifier of Min 2

Mus musculus

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Disease relevance of Mom2

  • The effects of the Mom2 locus on reducing polyp multiplicity are stronger than the effects of the Mom1 locus, in both the small and large intestines [1].
 

High impact information on Mom2

  • We now report the identification of a second Modifier of Min 2 (Mom2) locus that is the result of a spontaneous mutation [1].
  • Linkage analysis has localized Mom2 to distal mouse chromosome 18 [1].
  • One resistant Mom2 allele can suppress 88%-95% of polyps detected in Apc(Min)/+ mice, indicating that Mom2 acts in a dominant fashion [1].
  • Thus, the resistant Mom2 allele can, in some cases, completely suppress the penetrance of the Apc(Min) mutation [1].
 

Other interactions of Mom2

  • Through linkage analysis, we previously localized Mom2 to a 14-cM region on mouse Chromosome (Chr) 18, distal to the Apc gene [2].

References

  1. Identification of the modifier of Min 2 (Mom2) locus, a new mutation that influences Apc-induced intestinal neoplasia. Silverman, K.A., Koratkar, R., Siracusa, L.D., Buchberg, A.M. Genome Res. (2002) [Pubmed]
  2. Exclusion of Madh2, Madh4, and Madh7 as candidates for the modifier of Min 2 (Mom2) locus. Silverman, K.A., Koratkar, R.A., Siracusa, L.D., Buchberg, A.M. Mamm. Genome (2003) [Pubmed]
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