Gene Review:
Apc - adenomatosis polyposis coli
Mus musculus
Synonyms:
AI047805, AU020952, AW124434, Adenomatous polyposis coli protein, CC1, ...
- Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Oshima, M., Dinchuk, J.E., Kargman, S.L., Oshima, H., Hancock, B., Kwong, E., Trzaskos, J.M., Evans, J.F., Taketo, M.M. Cell (1996)
- Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling. Kielman, M.F., Rindapää, M., Gaspar, C., van Poppel, N., Breukel, C., van Leeuwen, S., Taketo, M.M., Roberts, S., Smits, R., Fodde, R. Nat. Genet. (2002)
- Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor. Lal, G., Ash, C., Hay, K., Redston, M., Kwong, E., Hancock, B., Mak, T., Kargman, S., Evans, J.F., Gallinger, S. Cancer Res. (2001)
- Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. Seno, H., Oshima, M., Ishikawa, T.O., Oshima, H., Takaku, K., Chiba, T., Narumiya, S., Taketo, M.M. Cancer Res. (2002)
- Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction. Wagenaar-Miller, R.A., Hanley, G., Shattuck-Brandt, R., DuBois, R.N., Bell, R.L., Matrisian, L.M., Morgan, D.W. Br. J. Cancer (2003)
- A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity. Haigis, K.M., Dove, W.F. Nat. Genet. (2003)
- Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis. Kitamura, T., Kawamori, T., Uchiya, N., Itoh, M., Noda, T., Matsuura, M., Sugimura, T., Wakabayashi, K. Carcinogenesis (2002)
- Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos. Jacoby, R.F., Cole, C.E., Tutsch, K., Newton, M.A., Kelloff, G., Hawk, E.T., Lubet, R.A. Cancer Res. (2000)
- Suppression of intestinal polyp development by nimesulide, a selective cyclooxygenase-2 inhibitor, in Min mice. Nakatsugi, S., Fukutake, M., Takahashi, M., Fukuda, K., Isoi, T., Taniguchi, Y., Sugimura, T., Wakabayashi, K. Jpn. J. Cancer Res. (1997)
- Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Takaku, K., Oshima, M., Miyoshi, H., Matsui, M., Seldin, M.F., Taketo, M.M. Cell (1998)
- Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon. Perreault, N., Sackett, S.D., Katz, J.P., Furth, E.E., Kaestner, K.H. Genes Dev. (2005)
- Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts. Smits, R., van der Houven van Oordt, W., Luz, A., Zurcher, C., Jagmohan-Changur, S., Breukel, C., Khan, P.M., Fodde, R. Gastroenterology (1998)
- Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers. Halberg, R.B., Katzung, D.S., Hoff, P.D., Moser, A.R., Cole, C.E., Lubet, R.A., Donehower, L.A., Jacoby, R.F., Dove, W.F. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Identification of the modifier of Min 2 (Mom2) locus, a new mutation that influences Apc-induced intestinal neoplasia. Silverman, K.A., Koratkar, R., Siracusa, L.D., Buchberg, A.M. Genome Res. (2002)
- Progressive changes in adherens junction structure during intestinal adenoma formation in Apc mutant mice. Carothers, A.M., Melstrom, K.A., Mueller, J.D., Weyant, M.J., Bertagnolli, M.M. J. Biol. Chem. (2001)
- Dysregulated expression of beta-catenin marks early neoplastic change in Apc mutant mice, but not all lesions arising in Msh2 deficient mice. Kongkanuntn, R., Bubb, V.J., Sansom, O.J., Wyllie, A.H., Harrison, D.J., Clarke, A.R. Oncogene (1999)
- Cells heterozygous for the ApcMin mutation have decreased gap junctional intercellular communication and connexin43 level, and reduced microtubule polymerization. Husøy, T., Cruciani, V., Knutsen, H.K., Mikalsen, S.O., Ølstørn, H.B., Alexander, J. Carcinogenesis (2003)
- Modulation of tumor formation and intestinal cell migration by estrogens in the Apc(Min/+) mouse model of colorectal cancer. Javid, S.H., Moran, A.E., Carothers, A.M., Redston, M., Bertagnolli, M.M. Carcinogenesis (2005)
- The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis. Jacoby, R.F., Seibert, K., Cole, C.E., Kelloff, G., Lubet, R.A. Cancer Res. (2000)
- Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice. Moran, A.E., Hunt, D.H., Javid, S.H., Redston, M., Carothers, A.M., Bertagnolli, M.M. J. Biol. Chem. (2004)
- Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. Choi, H.J., Huber, A.H., Weis, W.I. J. Biol. Chem. (2006)
- Gadd45a regulates matrix metalloproteinases by suppressing DeltaNp63alpha and beta-catenin via p38 MAP kinase and APC complex activation. Hildesheim, J., Belova, G.I., Tyner, S.D., Zhou, X., Vardanian, L., Fornace, A.J. Oncogene (2004)
- Emergent issues in the genetics of intestinal neoplasia. Dove, W.F., Gould, K.A., Luongo, C., Moser, A.R., Shoemaker, A.R. Cancer Surv. (1995)
- EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration. Wen, Y., Eng, C.H., Schmoranzer, J., Cabrera-Poch, N., Morris, E.J., Chen, M., Wallar, B.J., Alberts, A.S., Gundersen, G.G. Nat. Cell Biol. (2004)
- The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain. Erdmann, K.S., Kuhlmann, J., Lessmann, V., Herrmann, L., Eulenburg, V., Müller, O., Heumann, R. Oncogene (2000)
- The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells. Senda, T., Miyashiro, I., Matsumine, A., Baeg, G.H., Monden, T., Kobayashil, S., Monden, M., Toyoshima, K., Akiyama, T. Biochem. Biophys. Res. Commun. (1996)
- The distinct spectra of tumor-associated Apc mutations in mismatch repair-deficient Apc1638N mice define the roles of MSH3 and MSH6 in DNA repair and intestinal tumorigenesis. Kuraguchi, M., Yang, K., Wong, E., Avdievich, E., Fan, K., Kolodner, R.D., Lipkin, M., Brown, A.M., Kucherlapati, R., Edelmann, W. Cancer Res. (2001)
- Msh2 deficiency enhances somatic Apc and p53 mutations in Apc+/-Msh2-/- mice. Sohn, K.J., Choi, M., Song, J., Chan, S., Medline, A., Gallinger, S., Kim, Y.I. Carcinogenesis (2003)
- E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice. Smits, R., Ruiz, P., Diaz-Cano, S., Luz, A., Jagmohan-Changur, S., Breukel, C., Birchmeier, C., Birchmeier, W., Fodde, R. Gastroenterology (2000)
- Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Chulada, P.C., Thompson, M.B., Mahler, J.F., Doyle, C.M., Gaul, B.W., Lee, C., Tiano, H.F., Morham, S.G., Smithies, O., Langenbach, R. Cancer Res. (2000)
- Truncated mouse adenomatous polyposis coli reduces connexin32 content and increases matrilysin secretion from Paneth cells. Husøy, T., Ølstørn, H.B., Knutsen, H.K., Løberg, E.M., Cruciani, V., Mikalsen, S.O., Goverud, I.L., Alexander, J. Eur. J. Cancer (2004)
- Elevated cyclooxygenase-2 levels in Min mouse adenomas. Williams, C.S., Luongo, C., Radhika, A., Zhang, T., Lamps, L.W., Nanney, L.B., Beauchamp, R.D., DuBois, R.N. Gastroenterology (1996)
- Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice. Hansen-Petrik, M.B., McEntee, M.F., Jull, B., Shi, H., Zemel, M.B., Whelan, J. Cancer Res. (2002)
- Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522. Sasai, H., Masaki, M., Wakitani, K. Carcinogenesis (2000)
- Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene. Hasegawa, S., Sato, T., Akazawa, H., Okada, H., Maeno, A., Ito, M., Sugitani, Y., Shibata, H., Miyazaki Ji, J., Katsuki, M., Yamauchi, Y., Yamamura Ki, K., Katamine, S., Noda, T. Proc. Natl. Acad. Sci. U.S.A. (2002)