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Gene Review:

LOC1720 - dihydrofolate reductase pseudogene

Homo sapiens

Anagnou, N.P. et al., Pérez-Lezaun, A. et al., Wu, J.S. et al.

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High impact information on LOC1720

By genomic DNA analysis of a panel of human X rodent somatic-cell hybrids, we determined the chromosomal assignment of the DHFRP1 pseudogene to chromosome 18 and that of the DHFRP2 pseudogene to chromosome 6 [1].
The DHFRP1 pseudogene exhibits a novel form of polymorphism in humans in that it is present in the DNA of some individuals and absent in that of others [1].
This "presence/absence" type of polymorphism could be revealed by all of the 25 restriction enzymes tested and is similar in nature to that previously reported with one of the human dihydrofolate reductase pseudogenes, DHFRP1 [2].
An allele heterogeneity in a short tandem repeat at the human dihydrofolate reductase pseudogene (DHFRP2) was detected using non-denaturing gel electrophoresis and ethidium bromide staining [3].
Identification of a base pair substitution at the tetranucleotide tandem repeat locus DHFRP2 (AAAC)n in a worldwide survey [3].

References

Chromosomal localization and racial distribution of the polymorphic human dihydrofolate reductase pseudogene (DHFRP1). Anagnou, N.P., Antonarakis, S.E., O'Brien, S.J., Modi, W.S., Nienhuis, A.W. Am. J. Hum. Genet. (1988) [Pubmed]
The beta subunit locus of the human fibronectin receptor: DNA restriction fragment length polymorphism and linkage mapping studies. Wu, J.S., Giuffra, L.A., Goodfellow, P.J., Myers, S., Carson, N.L., Anderson, L., Hoyle, L.S., Simpson, N.E., Kidd, K.K. Hum. Genet. (1989) [Pubmed]
Identification of a base pair substitution at the tetranucleotide tandem repeat locus DHFRP2 (AAAC)n in a worldwide survey. Pérez-Lezaun, A., Calafell, F., Mateu, E., Comas, D., Bertranpetit, J. Int. J. Legal Med. (1996) [Pubmed]

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