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Gene Review:

mec-6 - Protein MEC-6

Caenorhabditis elegans

Chelur, D.S. et al., Harbinder, S. et al., Shreffler, W. et al., O'Hagan, R. et al.

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Disease relevance of paraoxonase\/arylesterase

Here we show that mec-6 encodes a single-pass membrane-spanning protein with limited similarity to paraoxonases, which are implicated in human coronary heart disease [1].
We found that ectopic expression of mec-4(d) in the nematode causes dysfunction of a wide range of nerve, muscle, and hypodermal cells. mec-4(d)-mediated toxicity is dependent on the activity of a second gene, mec-6, rendering cell disruption conditionally dependent on genetic background [2].

High impact information on paraoxonase\/arylesterase

This phenotype is completely suppressed by mutation in a third gene, mec-6 (refs 3, 4), that is needed for touch sensitivity [1].
Null mutations in the DEG/ENaC gene mec-4 and in the accessory ion channel subunit genes mec-2 and mec-6 eliminated MRCs [3].
As for previously identified deg-1 family members, unc-8 dominant mutations are recessively suppressed by mutations in the mec-6 gene, which probably encodes a second type of channel component [4].

References

The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel. Chelur, D.S., Ernstrom, G.G., Goodman, M.B., Yao, C.A., Chen, L., O' Hagan, R., Chalfie, M. Nature (2002) [Pubmed]
Genetically targeted cell disruption in Caenorhabditis elegans. Harbinder, S., Tavernarakis, N., Herndon, L.A., Kinnell, M., Xu, S.Q., Fire, A., Driscoll, M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals. O'Hagan, R., Chalfie, M., Goodman, M.B. Nat. Neurosci. (2005) [Pubmed]
The unc-8 and sup-40 genes regulate ion channel function in Caenorhabditis elegans motorneurons. Shreffler, W., Magardino, T., Shekdar, K., Wolinsky, E. Genetics (1995) [Pubmed]

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