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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Family

 
 
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Disease relevance of Family

 

Psychiatry related information on Family

 

High impact information on Family

  • The discovery of new functions for the original B7 family members, together with the identification of additional B7 and CD28 family members, have revealed new ways in which the B7:CD28 family regulates T cell activation and tolerance [11].
  • TNF/TNFR family members in costimulation of T cell responses [12].
  • The effects of these costimulatory TNFR family members can often be functionally, temporally, or spatially segregated from those of CD28 and from each other [12].
  • Therefore, these CIS family members seem to function in a classical negative feedback loop of cytokine signaling [13].
  • In the presence of oxygen, HIFalpha family members are hydroxylated on one of two conserved prolyl residues by members of the egg-laying-defective nine (EGLN) family [14].
 

Chemical compound and disease context of Family

 

Biological context of Family

 

Anatomical context of Family

 

Associations of Family with chemical compounds

  • To address the biological functions of the Eph family member Nuk, two mutations in the mouse germline have been generated: a protein null allele (Nuk1) and an allele that encodes a Nuk-beta gal fusion receptor lacking the tyrosine kinase and C-terminal domains (Nuk(lacZ)) [30].
  • The "BH3-only" proapoptotic BCL-2 family members are sentinels of intracellular damage [31].
  • CcpA is a LacI-GalR family member that employs, as an allosteric corepressor, the phosphoprotein HPr-Ser46-P, which is formed in glucose-replete conditions [32].
  • We screened affected family members for mutations within CHRNA4 and found a missense mutation that replaces serine with phenylalanine at codon 248, a strongly conserved amino acid residue in the second transmembrane domain [33].
  • Compared to other CPEB family members, the neuronal protein has an N-terminal extension that shares characteristics of yeast prion-determinants: a high glutamine content and predicted conformational flexibility [34].
 

Gene context of Family

 

Analytical, diagnostic and therapeutic context of Family

References

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