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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

mom-4  -  Protein MOM-4

Caenorhabditis elegans

 
 
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High impact information on mom-4

  • Here we show that the genes mom-4 and lit-1 are also required to downregulate POP-1, not only in E but also in other posterior daughter cells [1].
  • Here we show that mom-4, a genetically defined effector of polarity signaling, encodes a MAP kinase kinase kinase-related protein that stimulates the WRM-1/LIT-1-dependent phosphorylation of POP-1 [2].

References

  1. MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans. Meneghini, M.D., Ishitani, T., Carter, J.C., Hisamoto, N., Ninomiya-Tsuji, J., Thorpe, C.J., Hamill, D.R., Matsumoto, K., Bowerman, B. Nature (1999) [Pubmed]
  2. MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans. Shin, T.H., Yasuda, J., Rocheleau, C.E., Lin, R., Soto, M., Bei, Y., Davis, R.J., Mello, C.C. Mol. Cell (1999) [Pubmed]
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