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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

lit-1  -  Protein LIT-1

Caenorhabditis elegans

 
 
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High impact information on lit-1

  • Here we show that the genes mom-4 and lit-1 are also required to downregulate POP-1, not only in E but also in other posterior daughter cells [1].
  • Here we identify a gene, lit-1, that appears to play a central role in controlling the asymmetry of cell division during embryogenesis in C. elegans [2].
  • Therefore, wrm-1 and lit-1 are required for pop-1 function, rather than opposing it as observed in the early embryo [3].

References

  1. MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans. Meneghini, M.D., Ishitani, T., Carter, J.C., Hisamoto, N., Ninomiya-Tsuji, J., Thorpe, C.J., Hamill, D.R., Matsumoto, K., Bowerman, B. Nature (1999) [Pubmed]
  2. Binary specification of the embryonic lineage in Caenorhabditis elegans. Kaletta, T., Schnabel, H., Schnabel, R. Nature (1997) [Pubmed]
  3. POP-1 controls axis formation during early gonadogenesis in C. elegans. Siegfried, K.R., Kimble, J. Development (2002) [Pubmed]
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