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Gene Review:

mom-5 - Protein MOM-5

Caenorhabditis elegans

Umbhauer, M. et al., Hawkins, N.C. et al.

Hawkins, Ellis, Bowerman, Garriga,

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High impact information on mom-5

They are consistent with the genetic features exhibited by Drosophila Dfz3 and Caenorhabditis elegans mom-5 in which the tryptophan is substituted by a tyrosine [1].
Loss of mom-5, a C. elegans frizzled homolog, produced a similar phenotype [2].

References

The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling. Umbhauer, M., Djiane, A., Goisset, C., Penzo-Méndez, A., Riou, J.F., Boucaut, J.C., Shi, D.L. EMBO J. (2000) [Pubmed]
MOM-5 frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions. Hawkins, N.C., Ellis, G.C., Bowerman, B., Garriga, G. Dev. Biol. (2005) [Pubmed]

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