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Gene Review

vab-10  -  Protein VAB-10

Caenorhabditis elegans

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High impact information on vab-10

  • Our analysis of vab-10 reveals novel insights into the role of this plakin subfamily. vab-10 generates isoforms related either to plectin (termed VAB-10A) or to microtubule actin cross-linking factor plakins (termed VAB-10B) [1].
  • Here, we report the identification of new mutations in a gene known as vab-10, which lead to severe morphogenesis defects, and show that vab-10 corresponds to the C. elegans spectraplakin locus [1].
  • Nine new genes, named mua, and two previously published loci, unc-23 and vab-10, cause fragile musscle attachments [2].


  1. The Caenorhabditis elegans vab-10 spectraplakin isoforms protect the epidermis against internal and external forces. Bosher, J.M., Hahn, B.S., Legouis, R., Sookhareea, S., Weimer, R.M., Gansmuller, A., Chisholm, A.D., Rose, A.M., Bessereau, J.L., Labouesse, M. J. Cell Biol. (2003) [Pubmed]
  2. Fragile skeletal muscle attachments in dystrophic mutants of Caenorhabditis elegans: isolation and characterization of the mua genes. Plenefisch, J.D., Zhu, X., Hedgecock, E.M. Development (2000) [Pubmed]
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