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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

smu-1  -  Protein SMU-1

Caenorhabditis elegans

 
 
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High impact information on smu-1

  • We show that a presumptive null mutation in smu-1 suppresses nonsense mutations in exon 17 but not exon 18 of unc-52 and enhances the phenotype conferred by an unc-52 splice site mutation in intron 16 [1].
  • We propose that smu-1 encodes a trans-acting factor that regulates the alternative splicing of the pre-mRNA of unc-52 and other genes [1].
  • The suppressors, which define the genes smu-1 and smu-2, can weakly suppress all mec-8 mutant phenes [2].
 

Other interactions of smu-1

References

  1. Analysis of smu-1, a gene that regulates the alternative splicing of unc-52 pre-mRNA in Caenorhabditis elegans. Spike, C.A., Shaw, J.E., Herman, R.K. Mol. Cell. Biol. (2001) [Pubmed]
  2. The mec-8 gene of Caenorhabditis elegans affects muscle and sensory neuron function and interacts with three other genes: unc-52, smu-1 and smu-2. Lundquist, E.A., Herman, R.K. Genetics (1994) [Pubmed]
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