Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

smu-2 - Protein SMU-2

Caenorhabditis elegans

Spartz, A.K. et al., Lundquist, E.A. et al.

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High impact information on smu-2

Mutations in the Caenorhabditis elegans gene smu-2 suppress mec-8 and unc-52 mutations [1].
We conclude that smu-2 encodes a ubiquitously expressed nuclear protein that is 40% identical to the human RED protein, a component of purified spliceosomes [1].
The suppressors, which define the genes smu-1 and smu-2, can weakly suppress all mec-8 mutant phenes [2].

References

SMU-2 and SMU-1, Caenorhabditis elegans homologs of mammalian spliceosome-associated proteins RED and fSAP57, work together to affect splice site choice. Spartz, A.K., Herman, R.K., Shaw, J.E. Mol. Cell. Biol. (2004) [Pubmed]
The mec-8 gene of Caenorhabditis elegans affects muscle and sensory neuron function and interacts with three other genes: unc-52, smu-1 and smu-2. Lundquist, E.A., Herman, R.K. Genetics (1994) [Pubmed]

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