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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

dog-1  -  Protein DOG-1

Caenorhabditis elegans

 
 
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High impact information on dog-1

  • The mutator phenotype results from disruption of the predicted gene F33H2.1, which encodes a protein with characteristics of a DEAH helicase and which we have named dog-1 (for deletions of guanine-rich DNA) [1].
  • Nematodes mutated in dog-1 showed germline as well as somatic deletions in genes containing polyguanine tracts, such as vab-1 [1].
  • Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA [1].
  • Finally, we provide evidence that the small deletions generated in the dog-1 background are not formed through homologous recombination, nucleotide excision repair, or nonhomologous end-joining mechanisms, but appear to result from a mutagenic repair mechanism acting at G/C tracts [2].

References

  1. Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA. Cheung, I., Schertzer, M., Rose, A., Lansdorp, P.M. Nat. Genet. (2002) [Pubmed]
  2. Homologous recombination is required for genome stability in the absence of DOG-1 in Caenorhabditis elegans. Youds, J.L., O'Neil, N.J., Rose, A.M. Genetics (2006) [Pubmed]
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