Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

pod-2 - Protein POD-2

Caenorhabditis elegans

Rappleye, C.A. et al., Tagawa, A. et al.

Rappleye, Tagawa, Le Bot, Ahringer, Aroian,

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High impact information on pod-2

Genetic analyses indicate that pod-2 functions in the same pathway as pod-1 [1].
RESULTS: Mutation in either of two loci of this class, emb-8 and pod-2, disrupts embryonic polarization and results in osmotically-sensitive embryos [2].
Cloning of the previously characterized polarity gene pod-2 reveals it encodes acetyl-CoA carboxylase, an enzyme that catalyzes the first step in de novo fatty acid synthesis [2].

References

Pod-2, along with pod-1, defines a new class of genes required for polarity in the early Caenorhabditis elegans embryo. Tagawa, A., Rappleye, C.A., Aroian, R.V. Dev. Biol. (2001) [Pubmed]
Involvement of fatty acid pathways and cortical interaction of the pronuclear complex in Caenorhabditis elegans embryonic polarity. Rappleye, C.A., Tagawa, A., Le Bot, N., Ahringer, J., Aroian, R.V. BMC Dev. Biol. (2003) [Pubmed]

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