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Gene Review

emb-8  -  Protein EMB-8

Caenorhabditis elegans

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High impact information on emb-8

  • We find that mutants that disrupt anterior-posterior asymmetry in the early embryo (par-1-par-6, emb-8, Par(q537)) disrupt the spatial but not temporal control of GLP-1 expression: GLP-1 is observed at the normal stage of embryogenesis in par-like mutants; however, it is uniformly distributed [1].
  • RESULTS: Mutation in either of two loci of this class, emb-8 and pod-2, disrupts embryonic polarization and results in osmotically-sensitive embryos [2].
  • Loss of emb-8, a previously uncharacterized polarity gene, causes mislocalization of PAR-3 and PAR-2 that molecularly mark the anterior and posterior cortices. emb-8 encodes NADPH-cytochrome P450 reductase, a protein supplying electrons to cytochrome P450-family enzymes, some of which catalyze fatty acid modifications [2].


  1. Genes required for GLP-1 asymmetry in the early Caenorhabditis elegans embryo. Crittenden, S.L., Rudel, D., Binder, J., Evans, T.C., Kimble, J. Dev. Biol. (1997) [Pubmed]
  2. Involvement of fatty acid pathways and cortical interaction of the pronuclear complex in Caenorhabditis elegans embryonic polarity. Rappleye, C.A., Tagawa, A., Le Bot, N., Ahringer, J., Aroian, R.V. BMC Dev. Biol. (2003) [Pubmed]
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