Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

gld-3 - Protein GLD-3

Caenorhabditis elegans

Hasegawa, E. et al., Belfiore, M. et al., Otori, M. et al., Eckmann, C.R. et al.

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High impact information on gld-3

Finally, we found that gld-3 mog-6 mutants develop germline tumors, suggesting that mog-6 might function in the decision between mitosis and meiosis [1].
Conversely, a mutation in gld-3, a gene that functionally counteracts FBF, could partially restore oogenesis in the daz-1 mutant [2].
We also show that cpb-3 is likely to promote the meiotic entry in parallel with gld-3, a component of one of the redundant but essential genetic pathways for the entry to and progression through meiosis [3].
Furthermore, FBF acts largely upstream of gld-3 in the mitosis/meiosis decision [4].

References

Roles of the C. elegans cyclophilin-like protein MOG-6 in MEP-1 binding and germline fates. Belfiore, M., Pugnale, P., Saudan, Z., Puoti, A. Development (2004) [Pubmed]
The Caenorhabditis elegans homologue of deleted in azoospermia is involved in the sperm/oocyte switch. Otori, M., Karashima, T., Yamamoto, M. Mol. Biol. Cell (2006) [Pubmed]
C. elegans CPB-3 interacts with DAZ-1 and functions in multiple steps of germline development. Hasegawa, E., Karashima, T., Sumiyoshi, E., Yamamoto, M. Dev. Biol. (2006) [Pubmed]
GLD-3 and control of the mitosis/meiosis decision in the germline of Caenorhabditis elegans. Eckmann, C.R., Crittenden, S.L., Suh, N., Kimble, J. Genetics (2004) [Pubmed]

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