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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Oogenesis


Psychiatry related information on Oogenesis

  • The risk of expansion during oogenesis to the full mutation associated with mental retardation increases with the number of repeats, and this variation in risk accounts for the Sherman paradox [4].
  • The finding that SP can elicit equally all changes observed after copulation suggests that in the sexually mature female it is the major component controlling and stimulating oogenesis after mating [5].

High impact information on Oogenesis

  • To elucidate the role of the meiosis-specific cohesin SMC1beta (encoded by Smc1l2) in oogenesis, we carried out meiotic studies of female SMC1beta-deficient mice [6].
  • Ovarian development and oogenesis through the early stages of fertilization are evidently unimpaired, but most embryos from Zar1(-/-) females arrest at the one-cell stage [7].
  • D-cbl, a negative regulator of the Egfr pathway, is required for dorsoventral patterning in Drosophila oogenesis [8].
  • VegT is a T-box transcription factor whose mRNA is synthesized during oogenesis and localized in the vegetal hemisphere of the egg and early embryo [9].
  • To avoid inappropriate activation of nos, osk activity must appear only at the posterior pole of the oocyte, where the osk mRNA becomes localized during oogenesis [10].

Chemical compound and disease context of Oogenesis


Biological context of Oogenesis


Anatomical context of Oogenesis


Associations of Oogenesis with chemical compounds


Gene context of Oogenesis


Analytical, diagnostic and therapeutic context of Oogenesis


  1. Nucleocytoplasmic distribution of snRNPs and stockpiled snRNA-binding proteins during oogenesis and early development in Xenopus laevis. Zeller, R., Nyffenegger, T., De Robertis, E.M. Cell (1983) [Pubmed]
  2. Identification and characterization of a sphingolipid delta 4-desaturase family. Ternes, P., Franke, S., Zähringer, U., Sperling, P., Heinz, E. J. Biol. Chem. (2002) [Pubmed]
  3. Stage-specific localization of the small heat shock protein Hsp27 during oogenesis in Drosophila melanogaster. Marin, R., Tanguay, R.M. Chromosoma (1996) [Pubmed]
  4. Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox. Fu, Y.H., Kuhl, D.P., Pizzuti, A., Pieretti, M., Sutcliffe, J.S., Richards, S., Verkerk, A.J., Holden, J.J., Fenwick, R.G., Warren, S.T. Cell (1991) [Pubmed]
  5. Mating and sex peptide stimulate the accumulation of yolk in oocytes of Drosophila melanogaster. Soller, M., Bownes, M., Kubli, E. Eur. J. Biochem. (1997) [Pubmed]
  6. SMC1beta-deficient female mice provide evidence that cohesins are a missing link in age-related nondisjunction. Hodges, C.A., Revenkova, E., Jessberger, R., Hassold, T.J., Hunt, P.A. Nat. Genet. (2005) [Pubmed]
  7. Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition. Wu, X., Viveiros, M.M., Eppig, J.J., Bai, Y., Fitzpatrick, S.L., Matzuk, M.M. Nat. Genet. (2003) [Pubmed]
  8. D-cbl, a negative regulator of the Egfr pathway, is required for dorsoventral patterning in Drosophila oogenesis. Pai, L.M., Barcelo, G., Schüpbach, T. Cell (2000) [Pubmed]
  9. The role of maternal VegT in establishing the primary germ layers in Xenopus embryos. Zhang, J., Houston, D.W., King, M.L., Payne, C., Wylie, C., Heasman, J. Cell (1998) [Pubmed]
  10. Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential. Kim-Ha, J., Kerr, K., Macdonald, P.M. Cell (1995) [Pubmed]
  11. Heat stress affects oogenesis differently in wild-type Drosophila virilis and a mutant with altered juvenile hormone and 20-hydroxyecdysone levels. Gruntenko, N.E., Bownes, M., Terashima, J., Sukhanova, M.Z.h., Raushenbach, I.Y. Insect Mol. Biol. (2003) [Pubmed]
  12. Xenopus 5S gene transcription factor, TFIIIA: characterization of a cDNA clone and measurement of RNA levels throughout development. Ginsberg, A.M., King, B.O., Roeder, R.G. Cell (1984) [Pubmed]
  13. slow border cells, a locus required for a developmentally regulated cell migration during oogenesis, encodes Drosophila C/EBP. Montell, D.J., Rorth, P., Spradling, A.C. Cell (1992) [Pubmed]
  14. Control of the sperm-oocyte switch in Caenorhabditis elegans hermaphrodites by the fem-3 3' untranslated region. Ahringer, J., Kimble, J. Nature (1991) [Pubmed]
  15. Isolation of the dorsal locus of Drosophila. Steward, R., McNally, F.J., Schedl, P. Nature (1984) [Pubmed]
  16. okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis. Ghabrial, A., Ray, R.P., Schüpbach, T. Genes Dev. (1998) [Pubmed]
  17. Biosynthesis of the major zona pellucida glycoprotein secreted by oocytes during mammalian oogenesis. Greve, J.M., Salzmann, G.S., Roller, R.J., Wassarman, P.M. Cell (1982) [Pubmed]
  18. Germ line and soma cooperate during oogenesis to establish the dorsoventral pattern of egg shell and embryo in Drosophila melanogaster. Schüpbach, T. Cell (1987) [Pubmed]
  19. Staufen: a common component of mRNA transport in oocytes and neurons? Roegiers, F., Jan, Y.N. Trends Cell Biol. (2000) [Pubmed]
  20. Drosophila development requires spectrin network formation. Deng, H., Lee, J.K., Goldstein, L.S., Branton, D. J. Cell Biol. (1995) [Pubmed]
  21. PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis. Ishimaru, S., Ueda, R., Hinohara, Y., Ohtani, M., Hanafusa, H. EMBO J. (2004) [Pubmed]
  22. Reduction in oocyte number following prenatal exposure to a diet high in galactose. Chen, Y.T., Mattison, D.R., Feigenbaum, L., Fukui, H., Schulman, J.D. Science (1981) [Pubmed]
  23. Recent advances in understanding signal transduction pathways in worms and flies. Duffy, J.B., Perrimon, N. Curr. Opin. Cell Biol. (1996) [Pubmed]
  24. Myosin light chain-activating phosphorylation sites are required for oogenesis in Drosophila. Jordan, P., Karess, R. J. Cell Biol. (1997) [Pubmed]
  25. Profile of a mammalian sperm receptor. Wassarman, P.M. Development (1990) [Pubmed]
  26. An RNA-binding protein from Xenopus oocytes is associated with specific message sequences. Crawford, D.R., Richter, J.D. Development (1987) [Pubmed]
  27. The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis. Ghiglione, C., Carraway, K.L., Amundadottir, L.T., Boswell, R.E., Perrimon, N., Duffy, J.B. Cell (1999) [Pubmed]
  28. The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGF alpha-like protein. Neuman-Silberberg, F.S., Schüpbach, T. Cell (1993) [Pubmed]
  29. Implications for bcd mRNA localization from spatial distribution of exu protein in Drosophila oogenesis. Wang, S., Hazelrigg, T. Nature (1994) [Pubmed]
  30. Specific isoforms of squid, a Drosophila hnRNP, perform distinct roles in Gurken localization during oogenesis. Norvell, A., Kelley, R.L., Wehr, K., Schüpbach, T. Genes Dev. (1999) [Pubmed]
  31. An Egalitarian-BicaudalD complex is essential for oocyte specification and axis determination in Drosophila. Mach, J.M., Lehmann, R. Genes Dev. (1997) [Pubmed]
  32. Regulation of cytoplasmic dynein function in vivo by the Drosophila Glued complex. McGrail, M., Gepner, J., Silvanovich, A., Ludmann, S., Serr, M., Hays, T.S. J. Cell Biol. (1995) [Pubmed]
  33. Regulatory mechanisms required for DE-cadherin function in cell migration and other types of adhesion. Pacquelet, A., Rørth, P. J. Cell Biol. (2005) [Pubmed]
  34. Constitutive expression of a somatic heat-inducible hsp70 gene during amphibian oogenesis. Billoud, B., Rodriguez-Martin, M.L., Berard, L., Moreau, N., Angelier, N. Development (1993) [Pubmed]
  35. Xenopus annexin II (calpactin I) heavy chain has a distinct amino terminus. Izant, J.G., Bryson, L.J. J. Biol. Chem. (1991) [Pubmed]
  36. hunchback, a gene required for segmentation of an anterior and posterior region of the Drosophila embryo. Lehmann, R., Nüsslein-Volhard, C. Dev. Biol. (1987) [Pubmed]
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