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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Meiosis


High impact information on Meiosis

  • It is concluded on balance that the evidence points to a need for phosphoinositide/calcium signaling during resumption of meiosis [6].
  • Differently regulated APCs (APC(Cdh1), APC(Ama1)) have not been implicated in securin degradation at meiosis I [7].
  • Here we show that Mnd2, a subunit of the anaphase-promoting complex (APC/C) from budding yeast, is essential to prevent premature destruction of cohesion in meiosis [8].
  • (2005) show that mice with a mutation in the meiosis-specific cohesin protein SMC1beta exhibit age-dependent defects in meiosis [9].
  • Drosophila MEI-S332 and fungal Sgo1 genes are essential for sister centromere cohesion in meiosis I [10].

Chemical compound and disease context of Meiosis


Biological context of Meiosis


Anatomical context of Meiosis


Associations of Meiosis with chemical compounds


Gene context of Meiosis

  • We conclude that IME1 is a positive regulator of meiosis that normally is repressed by RME1 [27].
  • The RAD50 gene of S. cerevisiae is required during meiosis for both recombination and chromosome synapsis and is also required for repair of double strand breaks during vegetative growth [28].
  • Cyclin A1 is required for meiosis in the male mouse [29].
  • Early studies in yeast revealed a role for some of these proteins, including Msh5, in meiosis [30].
  • To assess the role of Mlh3 in mammalian meiosis, we have generated and characterized Mlh3(-/-) mice [31].

Analytical, diagnostic and therapeutic context of Meiosis


  1. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Xu, Y., Ashley, T., Brainerd, E.E., Bronson, R.T., Meyn, M.S., Baltimore, D. Genes Dev. (1996) [Pubmed]
  2. New polymorphisms at the DXS98 locus and confirmation of its location proximal to FRAXA by in situ hybridization. Schnur, R.E., Ledbetter, S.A., Ledbetter, D.H., Merry, D.E., Nussbaum, R.L. Am. J. Hum. Genet. (1989) [Pubmed]
  3. Atm inactivation results in aberrant telomere clustering during meiotic prophase. Pandita, T.K., Westphal, C.H., Anger, M., Sawant, S.G., Geard, C.R., Pandita, R.K., Scherthan, H. Mol. Cell. Biol. (1999) [Pubmed]
  4. Caenorhabditis elegans homologue of the human azoospermia factor DAZ is required for oogenesis but not for spermatogenesis. Karashima, T., Sugimoto, A., Yamamoto, M. Development (2000) [Pubmed]
  5. Pertussis toxin inhibits 1-methyladenine-induced maturation in starfish oocytes. Shilling, F., Chiba, K., Hoshi, M., Kishimoto, T., Jaffe, L.A. Dev. Biol. (1989) [Pubmed]
  6. Calcium at fertilization and in early development. Whitaker, M. Physiol. Rev. (2006) [Pubmed]
  7. Mnd2, an essential antagonist of the anaphase-promoting complex during meiotic prophase. Penkner, A.M., Prinz, S., Ferscha, S., Klein, F. Cell (2005) [Pubmed]
  8. The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1. Oelschlaegel, T., Schwickart, M., Matos, J., Bogdanova, A., Camasses, A., Havlis, J., Shevchenko, A., Zachariae, W. Cell (2005) [Pubmed]
  9. Cohesin and the maternal age effect. Gilliland, W.D., Hawley, R.S. Cell (2005) [Pubmed]
  10. Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis. Salic, A., Waters, J.C., Mitchison, T.J. Cell (2004) [Pubmed]
  11. Selective transcriptional down-regulation of anther invertases precedes the failure of pollen development in water-stressed wheat. Koonjul, P.K., Minhas, J.S., Nunes, C., Sheoran, I.S., Saini, H.S. J. Exp. Bot. (2005) [Pubmed]
  12. Aneuploidy in mouse metaphase II oocytes exposed in vivo and in vitro in preantral follicle culture to nocodazole. Sun, F., Betzendahl, I., Pacchierotti, F., Ranaldi, R., Smitz, J., Cortvrindt, R., Eichenlaub-Ritter, U. Mutagenesis (2005) [Pubmed]
  13. Polycystic ovarian condition in the dehydroepiandrosterone-treated rat model: hyperandrogenism and the resumption of meiosis are major initial events associated with cystogenesis of antral follicles. Anderson, E., Lee, G.Y., O'Brien, K. Anat. Rec. (1997) [Pubmed]
  14. Segregation of recombined chromosomes in meiosis I requires DNA topoisomerase II. Rose, D., Thomas, W., Holm, C. Cell (1990) [Pubmed]
  15. DNA binding and meiotic chromosomal localization of the Drosophila nod kinesin-like protein. Afshar, K., Barton, N.R., Hawley, R.S., Goldstein, L.S. Cell (1995) [Pubmed]
  16. Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation. Lincoln, A.J., Wickramasinghe, D., Stein, P., Schultz, R.M., Palko, M.E., De Miguel, M.P., Tessarollo, L., Donovan, P.J. Nat. Genet. (2002) [Pubmed]
  17. Molecular mimicry in development: identification of ste11+ as a substrate and mei3+ as a pseudosubstrate inhibitor of ran1+ kinase. Li, P., McLeod, M. Cell (1996) [Pubmed]
  18. glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans. Austin, J., Kimble, J. Cell (1987) [Pubmed]
  19. Transmeiotic differentiation of male germ cells in culture. Rassoulzadegan, M., Paquis-Flucklinger, V., Bertino, B., Sage, J., Jasin, M., Miyagawa, K., van Heyningen, V., Besmer, P., Cuzin, F. Cell (1993) [Pubmed]
  20. Emi1 is required for cytostatic factor arrest in vertebrate eggs. Reimann, J.D., Jackson, P.K. Nature (2002) [Pubmed]
  21. MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis. Srayko, M., Buster, D.W., Bazirgan, O.A., McNally, F.J., Mains, P.E. Genes Dev. (2000) [Pubmed]
  22. Initiation of meiosis in yeast mutants defective in adenylate cyclase and cyclic AMP-dependent protein kinase. Matsumoto, K., Uno, I., Ishikawa, T. Cell (1983) [Pubmed]
  23. Disjunction of homologous chromosomes in meiosis I depends on proteolytic cleavage of the meiotic cohesin Rec8 by separin. Buonomo, S.B., Clyne, R.K., Fuchs, J., Loidl, J., Uhlmann, F., Nasmyth, K. Cell (2000) [Pubmed]
  24. Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis. Sen, D., Gilbert, W. Nature (1988) [Pubmed]
  25. Female infertility in mice lacking connexin 37. Simon, A.M., Goodenough, D.A., Li, E., Paul, D.L. Nature (1997) [Pubmed]
  26. Meiotic maturation in Xenopus laevis oocytes initiated by insulin. El-Etr, M., Schorderet-Slatkine, S., Baulieu, E.E. Science (1979) [Pubmed]
  27. IME1, a positive regulator gene of meiosis in S. cerevisiae. Kassir, Y., Granot, D., Simchen, G. Cell (1988) [Pubmed]
  28. Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination. Alani, E., Padmore, R., Kleckner, N. Cell (1990) [Pubmed]
  29. Cyclin A1 is required for meiosis in the male mouse. Liu, D., Matzuk, M.M., Sung, W.K., Guo, Q., Wang, P., Wolgemuth, D.J. Nat. Genet. (1998) [Pubmed]
  30. Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. Edelmann, W., Cohen, P.E., Kneitz, B., Winand, N., Lia, M., Heyer, J., Kolodner, R., Pollard, J.W., Kucherlapati, R. Nat. Genet. (1999) [Pubmed]
  31. Meiotic arrest and aneuploidy in MLH3-deficient mice. Lipkin, S.M., Moens, P.B., Wang, V., Lenzi, M., Shanmugarajah, D., Gilgeous, A., Thomas, J., Cheng, J., Touchman, J.W., Green, E.D., Schwartzberg, P., Collins, F.S., Cohen, P.E. Nat. Genet. (2002) [Pubmed]
  32. Relocation and distinct subcellular localization of p34cdc2-cyclin B complex at meiosis reinitiation in starfish oocytes. Ookata, K., Hisanaga, S., Okano, T., Tachibana, K., Kishimoto, T. EMBO J. (1992) [Pubmed]
  33. Genetic control of sex-dependent meiotic recombination in the major histocompatibility complex of the mouse. Shiroishi, T., Sagai, T., Hanzawa, N., Gotoh, H., Moriwaki, K. EMBO J. (1991) [Pubmed]
  34. SIAH1 targets the alternative splicing factor T-STAR for degradation by the proteasome. Venables, J.P., Dalgliesh, C., Paronetto, M.P., Skitt, L., Thornton, J.K., Saunders, P.T., Sette, C., Jones, K.T., Elliott, D.J. Hum. Mol. Genet. (2004) [Pubmed]
  35. Shared roles of yeast glycogen synthase kinase 3 family members in nitrogen-responsive phosphorylation of meiotic regulator Ume6p. Xiao, Y., Mitchell, A.P. Mol. Cell. Biol. (2000) [Pubmed]
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