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Gene Review

clh-3  -  Protein CLH-3

Caenorhabditis elegans

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High impact information on clh-3

  • CONCLUSIONS: The inwardly rectifying Cl(-) current in C. elegans oocytes is due to the activity of a ClC channel encoded by clh-3 [1].

Anatomical context of clh-3

  • We recently identified a worm strain carrying a null allele of the clh-3 gene and utilized oocytes from these animals to characterize I(Cl,OR) biophysical properties [2].

Analytical, diagnostic and therapeutic context of clh-3

  • Double-stranded RNA-mediated gene interference (RNAi) and single-oocyte RT-PCR demonstrated that the channel is encoded by clh-3, one of six C. elegans ClC genes [1].


  1. CLH-3, a ClC-2 anion channel ortholog activated during meiotic maturation in C. elegans oocytes. Rutledge, E., Bianchi, L., Christensen, M., Boehmer, C., Morrison, R., Broslat, A., Beld, A.M., George, A.L., Greenstein, D., Strange, K. Curr. Biol. (2001) [Pubmed]
  2. Characterization of a novel voltage-dependent outwardly rectifying anion current in Caenorhabditis elegans oocytes. Yin, X., Denton, J., Yan, X., Strange, K. Am. J. Physiol., Cell Physiol. (2007) [Pubmed]
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