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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ptp-3  -  Protein PTP-3

Caenorhabditis elegans

 
 
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Disease relevance of ptp-3

  • A protein tyrosine phosphatase-like protein from baculovirus has RNA 5'-triphosphatase and diphosphatase activities [1].
 

High impact information on ptp-3

  • The genetic interaction of vab-1 and ptp-3 suggests that LAR-like RPTPs and Eph receptors have related and partly redundant functions in C. elegans morphogenesis [2].
  • Loss of function in ptp-3 synergistically enhances phenotypes of mutations in the C. elegans Eph receptor VAB-1 and a subset of its ephrin ligands, but does not show specific interactions with several other RTKs or morphogenetic mutants [2].
  • Loss of function in ptp-3 causes low-penetrance defects in gastrulation and epidermal development similar to those of VAB-1 Eph receptor tyrosine kinase mutants [2].
  • Inhibition of netrin-mediated axon attraction by a receptor protein tyrosine phosphatase [3].

References

  1. A protein tyrosine phosphatase-like protein from baculovirus has RNA 5'-triphosphatase and diphosphatase activities. Takagi, T., Taylor, G.S., Kusakabe, T., Charbonneau, H., Buratowski, S. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. The C. elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesis. Harrington, R.J., Gutch, M.J., Hengartner, M.O., Tonks, N.K., Chisholm, A.D. Development (2002) [Pubmed]
  3. Inhibition of netrin-mediated axon attraction by a receptor protein tyrosine phosphatase. Chang, C., Yu, T.W., Bargmann, C.I., Tessier-Lavigne, M. Science (2004) [Pubmed]
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