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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Baculoviridae

  • The vaccinia IL-1 beta receptor is secreted when expressed in a baculovirus system and competitively inhibited binding of IL-1 beta to the natural receptor on T cells [1].
  • The predicted amino acid sequence of a newly identified gene of the insect baculovirus Autographa californica nuclear polyhedrosis virus was similar to several uridine 5'-diphosphate (UDP)-glucuronosyl transferases and at least one UDP-glucosyl transferase [2].
  • Absorption of pathogenic autoantibodies by the extracellular domain of pemphigus vulgaris antigen (Dsg3) produced by baculovirus [3].
  • METHODS: We used a human CD1d (hCD1d) tetramer produced by a baculovirus expressing recombinant CD1d protein complexed with alpha-galactosylceramide (alpha-GalCer) and quantitated hCD1d tetramer reactive cells in blood and liver from controls and patients with primary biliary cirrhosis (PBC) [4].
  • It was recently shown that co-expression of adenovirus type 3 (Ad3) penton base and fibre in the baculovirus system produces dodecahedral particles, as does the expression of the penton base alone [5].

Psychiatry related information on Baculoviridae


High impact information on Baculoviridae

  • IAP death-preventing activity localizes to the N-terminal baculovirus IAP repeats, a motif found in both viral and cellular proteins associated with death prevention [7].
  • Ubiquitin is attached to membranes of baculovirus particles by a novel type of phospholipid anchor [8].
  • We have expressed CFTR in Sf9 insect cells using the baculovirus expression vector system [9].
  • We have purified wild-type and tumor-derived mutant p53 proteins expressed from baculovirus vectors and examined their interactions with SV40 DNA [10].
  • When expressed in COS-1 cells or in a baculovirus system, the cDNA conferred TNF binding properties comparable to the native receptor [11].

Chemical compound and disease context of Baculoviridae

  • The baculovirus fusogenic activity depends on the low pH conformation of virally-encoded trimeric glycoprotein, gp64 [12].
  • Recombinant baculoviruses were used to express wild-type serum response factor (SRF) and a mutant, SRF.CKIIA, which lacks all four serine residues in the major casein kinase II (CKII) site at residues 77-90 [13].
  • However, the N-glycosylation pathway of baculovirus-infected insect cells differs from the pathway found in higher eucaryotes, as indicated by the fact that glycoproteins produced in the baculovirus system typically lack complex biantennary N-linked oligosaccharide side chains containing penultimate galactose and terminal sialic acid residues [14].
  • In these experiments, we used the only candidate physiologic substrate identified as yet for c-Raf-1, mitogen-activated protein kinase kinase (MAPKK), to examine enzymatic characteristics and candidate modulators of c-Raf-1, c-Raf-1 was purified from Sf9 cells infected with recombinant baculovirus encoding a histidine-tagged c-Raf-1 [15].
  • The product of the baculovirus p35 gene is a specific inhibitor of a class of cysteine proteases termed caspases, and naturally functions in infected insects [16].

Biological context of Baculoviridae


Anatomical context of Baculoviridae

  • When infected with this recombinant baculovirus, the cell line Sf9, derived from the army-worm caterpillar S. frugiperda, expresses fully functional Shaker transient K+ currents, as assayed by whole-cell recording [21].
  • In this study, a CYP2A13 cDNA was prepared by RNA-PCR from human nasal mucosa and was translated using a baculovirus expression system [22].
  • To investigate the specific role of LBP in LPS activation of Kupffer cells, we produced a functional recombinant rat LBP using a baculovirus expression system, which we used to selectively examine the role of LBP's on Kupffer-cell function [23].
  • Based on specific steroid binding, insect cells infected with the recombinant baculovirus expressed 1-3 x 10(6) receptor molecules/cell which is 15-45 times more than that expressed normally in a hepatocyte [24].
  • Studies in this report investigated potential hemopoietic suppressive effects of human monokine induced by IFN-gamma (HuMig), a CXC chemokine that is chemotactic for activated lymphocytes. rHuMig was purified from Trichoplusia ni cells after infection with a recombinant baculovirus [25].

Gene context of Baculoviridae

  • A novel human CC chemokine complementary DNA was identified in a library constructed from human fetal RNA, cloned into a baculovirus vector, and expressed in Sf9 insect cells [26].
  • We have produced a soluble form of 4-1BBL using the baculovirus expression system [27].
  • Cleavage of c-IAP-1 or c-IAP-2 was not observed when interacting with the caspases, implying a different mechanism from the baculovirus p35 protein, the broad spectrum suicide inactivator of caspases [28].
  • Also, JAK2 was found to be constitutively associated with p95Vav in vivo when expressed at high levels in insect cells using baculovirus vectors [29].
  • Recombinant human RNPS1 expressed in baculovirus functionally synergizes with SR proteins and strongly activates splicing of both constitutively and alternatively spliced pre-mRNAs [30].

Analytical, diagnostic and therapeutic context of Baculoviridae


  1. A soluble receptor for interleukin-1 beta encoded by vaccinia virus: a novel mechanism of virus modulation of the host response to infection. Alcamí, A., Smith, G.L. Cell (1992) [Pubmed]
  2. A baculovirus blocks insect molting by producing ecdysteroid UDP-glucosyl transferase. O'Reilly, D.R., Miller, L.K. Science (1989) [Pubmed]
  3. Absorption of pathogenic autoantibodies by the extracellular domain of pemphigus vulgaris antigen (Dsg3) produced by baculovirus. Amagai, M., Hashimoto, T., Shimizu, N., Nishikawa, T. J. Clin. Invest. (1994) [Pubmed]
  4. Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human CD1d tetramer. Kita, H., Naidenko, O.V., Kronenberg, M., Ansari, A.A., Rogers, P., He, X.S., Koning, F., Mikayama, T., Van De Water, J., Coppel, R.L., Kaplan, M., Gershwin, M.E. Gastroenterology (2002) [Pubmed]
  5. Adenovirus 3 penton dodecahedron exhibits structural changes of the base on fibre binding. Schoehn, G., Fender, P., Chroboczek, J., Hewat, E.A. EMBO J. (1996) [Pubmed]
  6. Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells. Verdile, G., Groth, D., Mathews, P.M., St George-Hyslop, P., Fraser, P.E., Ramabhadran, T.V., Kwok, J.B., Schofield, P.R., Carter, T., Gandy, S., Martins, R.N. Mol. Psychiatry (2004) [Pubmed]
  7. Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death. Hay, B.A., Wassarman, D.A., Rubin, G.M. Cell (1995) [Pubmed]
  8. Ubiquitin is attached to membranes of baculovirus particles by a novel type of phospholipid anchor. Guarino, L.A., Smith, G., Dong, W. Cell (1995) [Pubmed]
  9. Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance. Kartner, N., Hanrahan, J.W., Jensen, T.J., Naismith, A.L., Sun, S.Z., Ackerley, C.A., Reyes, E.F., Tsui, L.C., Rommens, J.M., Bear, C.E. Cell (1991) [Pubmed]
  10. Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication. Bargonetti, J., Friedman, P.N., Kern, S.E., Vogelstein, B., Prives, C. Cell (1991) [Pubmed]
  11. Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor. Loetscher, H., Pan, Y.C., Lahm, H.W., Gentz, R., Brockhaus, M., Tabuchi, H., Lesslauer, W. Cell (1990) [Pubmed]
  12. Membrane fusion mediated by baculovirus gp64 involves assembly of stable gp64 trimers into multiprotein aggregates. Markovic, I., Pulyaeva, H., Sokoloff, A., Chernomordik, L.V. J. Cell Biol. (1998) [Pubmed]
  13. Casein kinase II phosphorylation increases the rate of serum response factor-binding site exchange. Marais, R.M., Hsuan, J.J., McGuigan, C., Wynne, J., Treisman, R. EMBO J. (1992) [Pubmed]
  14. Modifying the insect cell N-glycosylation pathway with immediate early baculovirus expression vectors. Jarvis, D.L., Finn, E.E. Nat. Biotechnol. (1996) [Pubmed]
  15. Enzymatic characteristics of the c-Raf-1 protein kinase. Force, T., Bonventre, J.V., Heidecker, G., Rapp, U., Avruch, J., Kyriakis, J.M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  16. Expression of the antiapoptotic baculovirus p35 gene in tomato blocks programmed cell death and provides broad-spectrum resistance to disease. Lincoln, J.E., Richael, C., Overduin, B., Smith, K., Bostock, R., Gilchrist, D.G. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  17. Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex. Xu, G., Cirilli, M., Huang, Y., Rich, R.L., Myszka, D.G., Wu, H. Nature (2001) [Pubmed]
  18. Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons. Chen, J., Kanai, Y., Cowan, N.J., Hirokawa, N. Nature (1992) [Pubmed]
  19. The head involution defective gene of Drosophila melanogaster functions in programmed cell death. Grether, M.E., Abrams, J.M., Agapite, J., White, K., Steller, H. Genes Dev. (1995) [Pubmed]
  20. PTP-PEST: a protein tyrosine phosphatase regulated by serine phosphorylation. Garton, A.J., Tonks, N.K. EMBO J. (1994) [Pubmed]
  21. Functional expression of Shaker K+ channels in a baculovirus-infected insect cell line. Klaiber, K., Williams, N., Roberts, T.M., Papazian, D.M., Jan, L.Y., Miller, C. Neuron (1990) [Pubmed]
  22. Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Su, T., Bao, Z., Zhang, Q.Y., Smith, T.J., Hong, J.Y., Ding, X. Cancer Res. (2000) [Pubmed]
  23. Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4. Su, G.L., Klein, R.D., Aminlari, A., Zhang, H.Y., Steinstraesser, L., Alarcon, W.H., Remick, D.G., Wang, S.C. Hepatology (2000) [Pubmed]
  24. Characterization and purification of a functional rat glucocorticoid receptor overexpressed in a baculovirus system. Alnemri, E.S., Maksymowych, A.B., Robertson, N.M., Litwack, G. J. Biol. Chem. (1991) [Pubmed]
  25. Suppressive effects of recombinant human monokine induced by IFN-gamma (rHuMig) chemokine on the number of committed and primitive hemopoietic progenitors in liquid cultures of CD34+ human bone marrow cells. Schwartz, G.N., Liao, F., Gress, R.E., Farber, J.M. J. Immunol. (1997) [Pubmed]
  26. Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. Uguccioni, M., Loetscher, P., Forssmann, U., Dewald, B., Li, H., Lima, S.H., Li, Y., Kreider, B., Garotta, G., Thelen, M., Baggiolini, M. J. Exp. Med. (1996) [Pubmed]
  27. CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand. Saoulli, K., Lee, S.Y., Cannons, J.L., Yeh, W.C., Santana, A., Goldstein, M.D., Bangia, N., DeBenedette, M.A., Mak, T.W., Choi, Y., Watts, T.H. J. Exp. Med. (1998) [Pubmed]
  28. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. Roy, N., Deveraux, Q.L., Takahashi, R., Salvesen, G.S., Reed, J.C. EMBO J. (1997) [Pubmed]
  29. Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL. Matsuguchi, T., Inhorn, R.C., Carlesso, N., Xu, G., Druker, B., Griffin, J.D. EMBO J. (1995) [Pubmed]
  30. Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing. Mayeda, A., Badolato, J., Kobayashi, R., Zhang, M.Q., Gardiner, E.M., Krainer, A.R. EMBO J. (1999) [Pubmed]
  31. Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function. Goyal, L., McCall, K., Agapite, J., Hartwieg, E., Steller, H. EMBO J. (2000) [Pubmed]
  32. Self-assembled B19 parvovirus capsids, produced in a baculovirus system, are antigenically and immunogenically similar to native virions. Kajigaya, S., Fujii, H., Field, A., Anderson, S., Rosenfeld, S., Anderson, L.J., Shimada, T., Young, N.S. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  33. Rapid inactivation of a moth pheromone. Ishida, Y., Leal, W.S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  34. The in vitro and in vivo phosphotyrosine map of activated MuSK. Watty, A., Neubauer, G., Dreger, M., Zimmer, M., Wilm, M., Burden, S.J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  35. Expression of human tyrosine hydroxylase cDNA in invertebrate cells using a baculovirus vector. Ginns, E.I., Rehavi, M., Martin, B.M., Weller, M., O'Malley, K.L., LaMarca, M.E., McAllister, C.G., Paul, S.M. J. Biol. Chem. (1988) [Pubmed]
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