Gene Review:
tcl-2 - Protein TCL-2
Caenorhabditis elegans
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High impact information on tcl-2
- Mutations in tcl-2 cause defects in the specification of the fates of the descendants of the TL and TR blast cells, whose polarity is regulated by lin-44/Wnt and lin-17/frizzled, during Caenorhabditis elegans development [1].
- In addition, tcl-2 mutations cause defects in the development of the gonad and the specification of fate of the posterior daughter of the P12 cell, both of which are controlled by the Wnt pathway [1].
References
- tcl-2 encodes a novel protein that acts synergistically with Wnt signaling pathways in C. elegans. Zhao, X., Sawa, H., Herman, M.A. Dev. Biol. (2003) [Pubmed]
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